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Archive for the ‘Named Reagents’ Category

Old reagent, new trick

Posted by naturalproductman on May 14, 2014

Ekaterina Budynina and co-workers from Moscow State University have used a Corey ylide to react with alpha,beta-unsaturated ketons to form dihydrofurans.

 
Corey ylide

OL paper

 

Posted in Cascade Reactions, Corey ylide, Methodology, Named Reagents | Leave a Comment »

Hydroacylation of ketones

Posted by naturalproductman on August 3, 2013

Vy Dong and colleague have reported in JACS on the use of Noyori’s catalyst to form chiral lactones, asymmetrically.
chiral

JACS paper

Posted in Asymmetric, Methodology, Noyori's transfer hydrogenation catalyst, Ruthenium, Transition Metal | Leave a Comment »

Kingianin synthesis

Posted by naturalproductman on March 6, 2013

Michael Sherburn and co-workers from Australian National University have reported in ACIE on the synthesis of kingianins A, D, and F from a poly-yne precursor.  Ledwith-Weitz salt was used to promote a Diels-Alder dimerization.

Diels-Alder

 

ACIE paper

Posted in Cascade Reactions, Diels-Alder, Ledwith-Weitz salt, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

Thiophenes from Simmons-Smith

Posted by naturalproductman on November 30, 2012

Kanchugarakoppal Rangappa and co-workers at the University of Mysore in India have reported in Tetrahedron Letters on the synthesis of thiophenes using a Simmons-Smith reagent.

thiophene

TL paper

Posted in Cascade Reactions, Copper, Methodology, Named Reagents, Simmons-Smith, Transition Metal, Zinc | Leave a Comment »

Tormesol via Wittig

Posted by naturalproductman on November 21, 2011

Dongjoo Lee and co-workers at Dankook University have reported in Tetrahedron on the synthesis of tormesol.  The seven membered ring was acquired from a Horner-Wadsworth-Emmons reaction.

Wittig

Tetrahedron paper

Posted in Horner-Wadsworth-Emmons, Methodology, Named Reactions, Named Reagents, Sesquiterpenoids, Total Synthesis, Wittig | Leave a Comment »

Regioselective epoxide opening

Posted by naturalproductman on October 23, 2011

Pilar López-Ram-de-Víu and co-workers have reported in Organic and Biomolecular Chemistry on an epoxide opening reaction using a Grignard reagent – and the regioselectivity is switched when they use it in the presence of copper bromide.

epoxide

OBC paper

Posted in Copper, Grignard, Methodology, Named Reactions, Named Reagents, Regioselective, Ring Opening, Transition Metal | Leave a Comment »

Olefin aminohydroxylation

Posted by naturalproductman on October 19, 2011

Istvan Marko and co-workers at Université catholique de Louvain in Belgium have reported in Tetrahedron on a nice synthesis of Telaprevir using an oxaziridine and a lithium amide to functionalize an alkene.

olefin

Tetrahedron paper

Posted in Cascade Reactions, Davies lithium amide, Diseases, Hepatitis C, Methodology, Multi-Component Coupling, Named Reagents, One pot | Leave a Comment »

Gelsemoxonine synthesis

Posted by naturalproductman on October 13, 2011

Tohru Fukuyama and co-workers have reported in JACS on a synthesis of gelsemoxonine featuring a divinylcyclopropane–cycloheptadiene rearrangement.

gelsemoxonine

JACS paper

Posted in Alkaloids, Asymmetric, Bredereck’s, Cascade Reactions, Methodology | Leave a Comment »

Polychlorinated natural product

Posted by naturalproductman on July 12, 2011

Erick Carreira and co-workers have reported in ACIEE on their synthesis of this lipid that contains eleven chlorines.

chlorosulfolipid

ACIEE paper

Posted in Julia-Kocienski, Martin sulfurane, Methodology, Named Reactions, Named Reagents | Leave a Comment »

Koser’s Reagent for Tetrahydrofurans

Posted by naturalproductman on January 18, 2011

Athannasios Giannis and co-workers at the Universitata Leipzig have used HTIB (Koser’s reagent:  [hydroxy(tosyloxy)iodo]benzene) to form tetrahydrofurans.

Koser's reagent

 

JOC paper

Posted in Hypervalent Iodine, Koser's, Methodology | Leave a Comment »

 
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