Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘New Setups’ Category

Forazoline A

Posted by naturalproductman on September 10, 2014

I thought I was going to have some down time before I posted again, but I ran into this interesting isolation paper of forazoline A that is worth a gander from Tim Bugni’s lab in the University of Wisconsin. They used a 15N-13C HMQC technique to determine which carbon was bonded to which nitrogen, which is apparently the first time this technique was used for a natural product. Looks like a pretty large natural product (m/z 901.4205). They have an interesting looking 13C NMR spectrum of the natural product (13C-labeled) that have splitting patterns on basically all of the carbons of the natural product (and thus looks like a proton NMR).

ACIE paper

Posted in Antifungal, New Setups, New Types, NMR, Polyketides, Polythio Compounds, Thiazoles | Leave a Comment »

ASAP HSQC

Posted by naturalproductman on January 20, 2014

Burkhard Luy and co-workers at Karlsruher Institut für Technologie in Germany have reported in JACS on a quick HSQC NMR method.
HSQC
JACS paper

Posted in New Setups, New Types, NMR | 1 Comment »

Making HSQC look nicer

Posted by naturalproductman on September 6, 2013

Gareth Morris and co-workers at the University of Manchester and beyond have reported in ACIE on enhancing the resolution of HSQC contours. I imagine this would be useful when carbon chemical shifts and proton chemical shifts are jumbled together.

HSQC

ACIE paper

Posted in New Setups, New Types | Leave a Comment »

Simplify proton NMR

Posted by naturalproductman on June 5, 2013

Klaus Zangger and co-worker at Karl-Franzens Universität Graz have reported in ACIE on a method to make your protons all look like singlets in your proton NMR.

ACIE paper

Posted in New Setups, New Types, Random | Leave a Comment »

Removing triphenylphosphine oxide

Posted by naturalproductman on May 14, 2013

I have had this silly problem in trying to get rid of triphenylphosphine oxide from my reaction mixture.  It’s stuck with my final product and can be a pain.  Some tricks I’ve seen are the use of dissolving mixture (O=PPh3 and product) in ether and run through short pad of silica.  This would be great if my product weren’t so polar – instead my product does not elute with ether.  Another trick was from this Lipshutz paper in 2003 where they used Merrifield resin to scavenge the phosphine.

 

OL paper

Posted in New Setups, New Types, Random | 10 Comments »

ATR-FTIR-UV/Vis monitoring of a reaction

Posted by naturalproductman on March 13, 2013

Ursula Bentrup and co-workers at Universitat Rostock in Germany have reported in Tetrahedron on an interesting setup to monitor a reaction.

monitor

Tetrahedron paper

Posted in Mechanistic, Methodology, New Setups, Titanium, Transition Metal | Leave a Comment »

Secondary alcohol stereochemistry

Posted by naturalproductman on April 17, 2012

Ion Ghiviriga at the University of Florida has reported in JOC on the use of NOESY1D to determine the stereochemistry of secondary alcohols by converting the alcohol to an MPA ester.

MPA

JOC paper

Posted in Methodology, New Setups, Stereochemistry | Leave a Comment »

Gliotoxin metabolites using DANS

Posted by naturalproductman on June 6, 2011

Frank Schroeder and co-workers at Cornell have reported in JACS on the isolation of gli dependent metabolites using differential analysis by 2D NMR spectroscopy (DANS).
gliotoxin

JACS paper

Posted in Chemical Biology, New Setups, Polythio Compounds | Leave a Comment »

Valproic Acid Monitoring

Posted by naturalproductman on March 6, 2011

Renato Zenobi and colleagues at ETH Zurich have reported in Chem Comm on a way to detect the pharmacokinetics of valproic acid, a drug used to treat epilepsy.

valproic acid

Chem Comm paper

Posted in Chemical Biology, Enzymatic, Metabolomics, Methodology, New Setups, Pharmacokinetics | Leave a Comment »

All in one flow!

Posted by naturalproductman on January 28, 2011

Timothy Jamison and co-workers have published in ACIEE on a continuous flow reactor way to synthesize nucleic acids.

nucleic acids

 

ACIEE paper

Posted in Methodology, New Setups | Leave a Comment »

 
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