I thought I was going to have some down time before I posted again, but I ran into this interesting isolation paper of forazoline A that is worth a gander from Tim Bugni’s lab in the University of Wisconsin. They used a 15N-13C HMQC technique to determine which carbon was bonded to which nitrogen, which is apparently the first time this technique was used for a natural product. Looks like a pretty large natural product (m/z 901.4205). They have an interesting looking 13C NMR spectrum of the natural product (13C-labeled) that have splitting patterns on basically all of the carbons of the natural product (and thus looks like a proton NMR).
Archive for the ‘New Types’ Category
Posted by naturalproductman on September 10, 2014
Posted by naturalproductman on August 20, 2014
Arjan Kleij and co-workers from ICIQ in Spain have reported in ACIE on the use of carbon dioxide as a protecting group for cis-diols arising from epoxides using an iron or aluminum aminotriphenolate complex to make the carbonate from the epoxide.
Posted by naturalproductman on January 20, 2014
Burkhard Luy and co-workers at Karlsruher Institut für Technologie in Germany have reported in JACS on a quick HSQC NMR method.
Posted by naturalproductman on September 6, 2013
Gareth Morris and co-workers at the University of Manchester and beyond have reported in ACIE on enhancing the resolution of HSQC contours. I imagine this would be useful when carbon chemical shifts and proton chemical shifts are jumbled together.
Posted by naturalproductman on June 5, 2013
Klaus Zangger and co-worker at Karl-Franzens Universität Graz have reported in ACIE on a method to make your protons all look like singlets in your proton NMR.
Posted by naturalproductman on May 14, 2013
I have had this silly problem in trying to get rid of triphenylphosphine oxide from my reaction mixture. It’s stuck with my final product and can be a pain. Some tricks I’ve seen are the use of dissolving mixture (O=PPh3 and product) in ether and run through short pad of silica. This would be great if my product weren’t so polar – instead my product does not elute with ether. Another trick was from this Lipshutz paper in 2003 where they used Merrifield resin to scavenge the phosphine.
Posted by naturalproductman on June 5, 2011
Robin Hoschstrasser and co-workers at UPenn have reported in Science on the use of 2D-IR spectroscopy to get the structure of a protein.
Posted by naturalproductman on June 8, 2010
Jerome Waser and co-workers at Ecole Polytechnique Fédérale de Lausanne in Switzerland have published on a cyclopropane ring opening strategy to synthesize goniomitine. The strategy was to use a vinyl cyclopropyl ketone and open the cyclopropane with pTsOH to generate a precursor for a homo-Nazarov cyclization to access the six membered ring fused with the indole ring.
Posted by naturalproductman on July 3, 2009
Shouheng Sun from Brown University has recently published in JACS on a target delivery of cisplatin to cancer cells using porous hollow nanoparticles (PHNP). They concluded that the nanoparticles deliver the cisplatin better at 2.9 micromolar IC50 towards breast cancer SK-BR-3 while without the nanoparticles, it’s activity is 6.8 micromolar.
Posted by naturalproductman on February 27, 2009
The ring contraction reaction is a pretty neat trick using a thallium reagent published by University of Basel in Switzerland and University of Sao Paulo in Brazil by Andreas Pfaltz and Luiz Silva and co-workers in JOC.
A review on ring contractions by Silva can be found in TL: