Naturalproductman’s Blog

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Archive for the ‘New Types’ Category

ASAP HSQC

Posted by naturalproductman on January 20, 2014

Burkhard Luy and co-workers at Karlsruher Institut für Technologie in Germany have reported in JACS on a quick HSQC NMR method.
HSQC
JACS paper

Posted in New Setups, New Types, NMR | 1 Comment »

Making HSQC look nicer

Posted by naturalproductman on September 6, 2013

Gareth Morris and co-workers at the University of Manchester and beyond have reported in ACIE on enhancing the resolution of HSQC contours. I imagine this would be useful when carbon chemical shifts and proton chemical shifts are jumbled together.

HSQC

ACIE paper

Posted in New Setups, New Types | Leave a Comment »

Simplify proton NMR

Posted by naturalproductman on June 5, 2013

Klaus Zangger and co-worker at Karl-Franzens Universität Graz have reported in ACIE on a method to make your protons all look like singlets in your proton NMR.

ACIE paper

Posted in New Setups, New Types, Random | Leave a Comment »

Removing triphenylphosphine oxide

Posted by naturalproductman on May 14, 2013

I have had this silly problem in trying to get rid of triphenylphosphine oxide from my reaction mixture.  It’s stuck with my final product and can be a pain.  Some tricks I’ve seen are the use of dissolving mixture (O=PPh3 and product) in ether and run through short pad of silica.  This would be great if my product weren’t so polar – instead my product does not elute with ether.  Another trick was from this Lipshutz paper in 2003 where they used Merrifield resin to scavenge the phosphine.

 

OL paper

Posted in New Setups, New Types, Random | 9 Comments »

2D-IR spectroscopy

Posted by naturalproductman on June 5, 2011

Robin Hoschstrasser and co-workers at UPenn have reported in Science on the use of 2D-IR spectroscopy to get the structure of a protein.

 

Science paper

Posted in New Types, Proteins | Leave a Comment »

Synthesis of Goniomitine

Posted by naturalproductman on June 8, 2010

Jerome Waser and co-workers at Ecole Polytechnique Fédérale de Lausanne in Switzerland have published on a cyclopropane ring opening  strategy to synthesize goniomitine.  The strategy was to use a vinyl cyclopropyl ketone and open the cyclopropane with pTsOH to generate a precursor for a homo-Nazarov cyclization to access the six membered ring fused with the indole ring.

cyclopropane

ACIEE paper

Posted in Cascade Reactions, Electrocyclization, Methodology, Named Reactions, Nazarov cyclization, New Types, Pericyclic reactions, Ring forming | Leave a Comment »

It’s not Delivery, it’s HNPO.

Posted by naturalproductman on July 3, 2009

Shouheng Sun from Brown University has recently published in JACS on a target delivery of cisplatin to cancer cells using porous hollow nanoparticles (PHNP).  They concluded that the nanoparticles deliver the cisplatin better at 2.9 micromolar IC50 towards breast cancer SK-BR-3 while without the nanoparticles, it’s activity is 6.8 micromolar. 

hnpo
JACS link

Posted in Methodology, New Types | Leave a Comment »

TTN Ring Contraction

Posted by naturalproductman on February 27, 2009

The ring contraction reaction is a pretty neat trick using a thallium reagent published by University of Basel in Switzerland and University of Sao Paulo in Brazil by Andreas Pfaltz and Luiz Silva and co-workers in JOC.

ttn-reaction


JOC paper

A review on ring contractions by Silva can be found in TL:
TL Review
ring contraction

Posted in New Types, Sesquiterpenes | Leave a Comment »

A Tandem Hydroalkoxylation-Hydroarylation Reaction

Posted by naturalproductman on February 7, 2009

Francisco J. Fananas at the Universidad de Oviedo in Spain has recently published a synthesis on bruguierol A, which is a natural product that shows modest antimicrobial activity.  The activity is okay, but the way they made the bicyclic ring system is really neat and worth checking out.

bruguierol A

The JOC paper here

Isolation paper

Posted in New Types | Leave a Comment »

 
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