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Archive for the ‘Oxazoles’ Category

Plantazolicin A synthesis

Posted by naturalproductman on November 28, 2014

Steven Ley and co-workers at the University of Cambridge have reported in ACIE on the syntheses of plantazolicins A and B.

thiazole

ACIE paper

Posted in Methodology, Oxazoles, Thiazoles, Total Synthesis | Leave a Comment »

Disorazole through cross metathesis

Posted by naturalproductman on November 8, 2014

Hoveyda and co-workers from Boston College have reported in JACS on a Z-selective cross coupling to access this C2-symmetric molecule – using alkenyl boronate and alkenyl iodide moieties.
metathesis

JACS paper

Posted in Alkaloids, C2-Symmetric, Metathesis, Methodology, Oxazoles, Ruthenium, Transition Metal | Leave a Comment »

Rhizopodin synthesis

Posted by naturalproductman on May 8, 2013

Ian Paterson and co-workers from the University of Cambridge have reported in ACIE on the synthesis of rhizopodin.

rhizopodin

ACIE paper

Posted in Macrolides, Methodology, Oxazoles, Total Synthesis | Leave a Comment »

Ajudazol B synthesis

Posted by naturalproductman on November 16, 2012

Dirk Menche and co-workers from the Universitat Bonn have reported in Organic Letters on a synthesis and stereochemical assignment from a bioinformatics study.

synthesis

JACS paper

Posted in Asymmetric, Bioinformatics, Computational, Methodology, Oxazoles, Polyenes | Leave a Comment »

Rhizopodin synthesis

Posted by naturalproductman on April 24, 2012

Dirk Menche and co-workers from Universität Heidelberg have reported in ACIE on the synthesis of rhizopodin.

rhizopodin

ACIE paper

Posted in C2-Symmetric, Macrolides, Methodology, Oxazoles, Total Synthesis | Leave a Comment »

Icumazole synthesis

Posted by naturalproductman on December 30, 2011

Rolf Muller and co-workers have reported in ACIEE on the isolation and total syntheses of icumazoles.

icumazole

ACIEE paper

Posted in Coumarins, Methodology, Oxazoles, Total Synthesis | Leave a Comment »

Oxazolomycin A synthesis

Posted by naturalproductman on September 4, 2011

Susumi Hatakeyama and co-workers from Nagasaki University have reported in Organic Letters on their synthesis of oxazolomycin A.

oxazole

OL paper

Posted in Methodology, Oxazoles, Polyenes, Spirocycles, Total Synthesis | Leave a Comment »

Peptides with oxazoles and thiazoles

Posted by naturalproductman on May 14, 2011

Roderich Sussmith and co-workers at the University of Berlin have reported in Organic Letters on the isolation of plantazolicins – oxazole and thiazole containing peptides.

oxazole

OL paper

Posted in Oxazoles, Peptides | Leave a Comment »

Deshydroxyajudazol B Synthesis

Posted by naturalproductman on March 16, 2011

Mark Rizzacasa and co-workers at the University of Melbourne have reported in Organic Letters on the synthesis of dehydroxyajudazol B.

total

 

OL paper

Posted in cross coupling, Cycloaddition, Diels-Alder, Methodology, Named Reactions, Oxazoles, Palladium, Pericyclic reactions, Sonogashira, Transition Metal | Leave a Comment »

Synoxazolidinone C

Posted by naturalproductman on March 14, 2011

Marge Tadesse and co-workers at have reported in Tetrahedron Letters on the isolation of synoxazolidinone C, which had an IC50 value of 30.5 μM against lung fibroblast cells (MRC-5).

synoxazolidinone C

TL paper

Posted in breast, Cancer, lung, melanoma, Oxazoles, oxazolidinone | Leave a Comment »

 
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