Naturalproductman’s Blog

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Archive for the ‘Peptides’ Category

Mannopeptimycin aglycone synthesis

Posted by naturalproductman on August 18, 2014

Takayuki Doi and co-workers at Tohoku University have reported in JACS on the synthesis of mannopeptimycin aglycone.

mannopeptimycin aglycone

JACS paper

Posted in Aldol, Methodology, Peptides | Leave a Comment »

1-Alaninechlamydocin

Posted by naturalproductman on July 15, 2014

Robert Cichewicz and co-workers from the University of Oklahoma have reported in the Journal of Natural Products on the isolation of a tetrapeptide with HDAC inhibitory activity. This compound was isolated from a fungus in Lake Superior.

peptide

JNP paper

Posted in Cancer, Histone deacetylase, Peptides, Protein Targets | Leave a Comment »

Polyketide-peptide hybrid

Posted by naturalproductman on June 28, 2014

Liangcheng Du and co-workers at University of Nebraska-Lincoln have reported in ACIE on a polyketide synthase–nonribosomal peptide synthetase that made a hybrid polyketide-peptide compound.

polyketide

ACIE paper

Posted in Chemical Biology, Hybrids, Peptides, Polyketides | Leave a Comment »

Stellatolides

Posted by naturalproductman on May 6, 2014

Carmen Cuevas and co-workers from PharmaMar in Spain have reported in JACS on the isolation and syntheses of stellatolides.

stellatolides

JACS paper

Posted in Cancer, Depsipeptides, Peptides, Total Synthesis | Leave a Comment »

Luciferin from earthworms

Posted by naturalproductman on April 18, 2014

Ilia Yampolsky and co-workers at the Russian Academy of Sciences have reported in ACIE on the isolation of luciferin from the luminous earthworm.

 

ACIE paper

Posted in Peptides, Polyenes | Leave a Comment »

MA026 synthesis

Posted by naturalproductman on December 9, 2013

Fumio Sugawara and co-workers at the Tokyo University of Science have reported in JACS on the synthesis of MA026 and its anti-hepatitis C virus activity.

HCV

JACS paper

Posted in Anti-viral, Diseases, Hepatitis C, Peptides, Total Synthesis | Leave a Comment »

Echinocandin C synthesis

Posted by naturalproductman on April 23, 2013

Markus Oberthür and colleague at Philipps-Universität Marburg reported in ACIE on the synthesis of echinocandin C.

echinocandin C

ACIE paper

Posted in Methodology, Peptides | Leave a Comment »

Yaku’amide A synthesis

Posted by naturalproductman on March 22, 2013

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of some peptides, yaku’amide A.

JACS paper

Posted in Cancer, leukemia, Methodology, Peptides, Total Synthesis | Leave a Comment »

Vancomycin analogs

Posted by naturalproductman on January 6, 2012

Whenever I see vancomycin’s structure I always think of Dale Boger. This time he and co-workers have published in JACS on the synthesis of some vancomycin analogs.
vancomycin

JACS paper

Posted in Methodology, Peptides, Total Synthesis, Unnatural Products | Leave a Comment »

Genetic engineering to diversify natural product structures

Posted by naturalproductman on December 30, 2011

Eric Schmidt and co-workers at the University of Utah have reported in JACS on a way to diversify natural products.

ribosomal

JACS paper

Posted in Chemical Biology, Peptides | Leave a Comment »

 
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