Naturalproductman’s Blog

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Archive for the ‘Peptides’ Category

Luciferin from earthworms

Posted by naturalproductman on April 18, 2014

Ilia Yampolsky and co-workers at the Russian Academy of Sciences have reported in ACIE on the isolation of luciferin from the luminous earthworm.

 

ACIE paper

Posted in Peptides, Polyenes | Leave a Comment »

MA026 synthesis

Posted by naturalproductman on December 9, 2013

Fumio Sugawara and co-workers at the Tokyo University of Science have reported in JACS on the synthesis of MA026 and its anti-hepatitis C virus activity.

HCV

JACS paper

Posted in Anti-viral, Diseases, Hepatitis C, Peptides, Total Synthesis | Leave a Comment »

Echinocandin C synthesis

Posted by naturalproductman on April 23, 2013

Markus Oberthür and colleague at Philipps-Universität Marburg reported in ACIE on the synthesis of echinocandin C.

echinocandin C

ACIE paper

Posted in Methodology, Peptides | Leave a Comment »

Yaku’amide A synthesis

Posted by naturalproductman on March 22, 2013

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of some peptides, yaku’amide A.

JACS paper

Posted in Cancer, leukemia, Methodology, Peptides, Total Synthesis | Leave a Comment »

Vancomycin analogs

Posted by naturalproductman on January 6, 2012

Whenever I see vancomycin’s structure I always think of Dale Boger. This time he and co-workers have published in JACS on the synthesis of some vancomycin analogs.
vancomycin

JACS paper

Posted in Methodology, Peptides, Total Synthesis, Unnatural Products | Leave a Comment »

Genetic engineering to diversify natural product structures

Posted by naturalproductman on December 30, 2011

Eric Schmidt and co-workers at the University of Utah have reported in JACS on a way to diversify natural products.

ribosomal

JACS paper

Posted in Chemical Biology, Peptides | Leave a Comment »

Burkholdac B synthesis

Posted by naturalproductman on November 17, 2011

Ganesan and co-workers at the University of Southampton have reported in Organic Letters on a synthesis of burkholdac B, which has an IC50 of 60 pM against MCF7 breast cancer cell lines.

burkholdac B

OL paper

Posted in breast, Cancer, Methodology, Peptides, Total Synthesis | Leave a Comment »

Proteomes vs. Disease

Posted by naturalproductman on October 30, 2011

Theo Luider and colleagues at Erasmus Medical Center in the Netherlands have reported in the Journal of Proteome Research on the higher concentration of PZP (Pregnancy Zone Protein) in presymptomatic Alzheimer’s disease group of women.

AD

Journal of Proteome Research paper

Posted in Alzheimer's, Diseases, Peptides, Proteomics | Leave a Comment »

Complestatin A an B syntheses

Posted by naturalproductman on October 20, 2011

Dale Boger and colleague have reported in JACS on their synthesis of  complestatin A and B.

complestatin

JACS paper

Posted in Methodology, Peptides, Total Synthesis | Leave a Comment »

Thailandespins

Posted by naturalproductman on October 14, 2011

Yi-Qiang Cheng and co-workers from the University of Wisconsin in Milwaukee have reported in the Journal of Natural Products on some disulfide compounds that have HDAC inhibitory activity – the compounds with the reduced disulfide bond was shown to be more active than the oxidized dithiol form.

disulfide bond

JNP paper

Posted in Cancer, Peptides, Polythio Compounds | Leave a Comment »

 
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