Echinocandin C synthesis

Markus Oberthür and colleague at Philipps-Universität Marburg reported in ACIE on the synthesis of echinocandin C.

ACIE paper

Yaku’amide A synthesis

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of some peptides, yaku’amide A.

JACS paper

Vancomycin analogs

Whenever I see vancomycin’s structure I always think of Dale Boger. This time he and co-workers have published in JACS on the synthesis of some vancomycin analogs.

JACS paper

Genetic engineering to diversify natural product structures

Eric Schmidt and co-workers at the University of Utah have reported in JACS on a way to diversify natural products.

JACS paper

Burkholdac B synthesis

Ganesan and co-workers at the University of Southampton have reported in Organic Letters on a synthesis of burkholdac B, which has an IC50 of 60 pM against MCF7 breast cancer cell lines.

OL paper

Proteomes vs. Disease

Theo Luider and colleagues at Erasmus Medical Center in the Netherlands have reported in the Journal of Proteome Research on the higher concentration of PZP (Pregnancy Zone Protein) in presymptomatic Alzheimer’s disease group of women.

Journal of Proteome Research paper

Complestatin A an B syntheses

Dale Boger and colleague have reported in JACS on their synthesis of  complestatin A and B.

JACS paper

Thailandespins

Yi-Qiang Cheng and co-workers from the University of Wisconsin in Milwaukee have reported in the Journal of Natural Products on some disulfide compounds that have HDAC inhibitory activity – the compounds with the reduced disulfide bond was shown to be more active than the oxidized dithiol form.

JNP paper

VEGF synthesis

Stephen Kent and colleague from the University of Chicago have reported in ACIEE on the total synthesis of a protein, VEGF.  You might be wondering, why would anybody want to synthesize a protein when you can just use a ribosome and translate the RNA into proteins?  Well when you can chemically synthesize these proteins, you can be creative and make the enantiomeric protein using the D-amino acids.

ACIEE paper

Bactolobin analogs

Jon Clardy and co-workers at Harvard have reported in Organic Letters on the isolation of some compounds by deleting certain genes in B. thailandensis.

OL paper