Gracilioether H has anti-malarial activity

Angela Zampella and co-workers have reported in Tetrahedron on the isolation of gracilioethers.  Gracilioether H had anti-malarial activity.

Tetrahedron paper

[2+2+2] for endoperoxides

Tehshik Yoon and co-workers at the University of Wisconsin have reported in Organic Letters on a [2+2+2] cyclization approach to form endoperoxides using oxygen (ie:  O2).

OL paper

Catharoseumine

Xiao-Jiang Hao and co-workers from the Kunming Institute of Botany have reported in Tetrahedron Letters on the isolation of catharoseumine a peroxy containing alkaloid.

TL paper

Cyclic peroxides from triketones

Alexander Terent’ev and co-workers from the Russian Academy of Sciences have reported in JOC on a method to form cyclic peroxides from triketones.

JOC paper

Merulin C lowers phosphorylation of Erk1/2

Khanitha Pudhom and co-workers have reported in the Journal of Natural Products on the isolation and activity of some endoperoxides from a Thai mangrove derived fungus.

JNP paper

Talaperoxides

Zhigang She and co-workers Sun-yat Sen University have reported in the Journal of Natural Products on the isolation of talaperoxides, norsesquiterpene peroxides.

JNP paper

Epiplakinidioic Acid

Abimael Rodriguez and co-workers from the University of Puerto Rico have published in the Journal of Natural Products on the isolation of epiplakinidioic acid, which had an IC50 value of 0.3 micromolar against Plasmodium falciporum.

 

JNP paper

Cytosporolides

Yongsheng Che and co-workers at the Chinese Academy of Sciences have published in Organic Letters on the isolation of meroterpenoids.

OL paper

Manadoperoxide Anti-Malarials

Orazio Taglialatela-Scafati and co-workers Universita di Napoli “Federico II” have published in the Journal of Natural Products on the isolation of manadoperoxides.

JNP paper

Merulins

Khanitha Pudhom and co-workers at Chulalongkorn University in Thailand have recently isolated some endoperoxides.  Merulins A and C have good bioactivity with IC50 values 4.98 and 1.57 μg/mL against BT474 cell lines.

JNP paper