Posted by naturalproductman on April 17, 2012
Johann Mulzer and co-workers at the University of Vienna have reported in Organic Letters on the synthesis of the tricyclic core of bielschowskysin. Surprisingly, that cyclobutane with the five membered ring is stable in many different conditions (ie: LiOH).
Posted in Cycloaddition, Cyclobutanes, Methodology, Pericyclic reactions, Polycyclic, [2+2] | Leave a Comment »
Posted by naturalproductman on March 25, 2011
Alessandro Bagno and co-workers at Universitat Padova have reported in JACS on the use of density functional theory and NMR to assign the stereochemistry to vannusal B.
Posted in Computational, Polycyclic, Terpenoids | Leave a Comment »
Posted by naturalproductman on February 10, 2011
Hisashi Yamamoto and co-workers at Chicago have published in ACIEE on a total synthesis of EBC-23 via the super silyl cascade reaction.
Posted in Cascade Reactions, Methodology, Polycyclic, Spiroketals | Leave a Comment »
Posted by naturalproductman on July 15, 2010
Yasuhiro Igarashi and co-workers from Toyama Prefectural University have published in Organic Letters on the isolation of alchivemycin A, a polycyclic polyketide that had MIC value of 50 nM against Micrococcus luteus.
Posted in Polycyclic, Polyketides | Leave a Comment »
Posted by naturalproductman on April 25, 2010
Robert Kiss and co-workers from Universite Libre de Bruxelles have recently identified bislongiquinolide and dihydrotrichodimerol from terrestrial fungi. Bislongiquinolide and dihydrotrichodimerol had IC50 values of 3 micromolar each against B16F10 cell lines.
Posted in Polycyclic, Polyenes | Leave a Comment »
Posted by naturalproductman on March 24, 2010
David Macmillan and co-worker at Princeton have recently published in JACS on a SOMO (singly occupied molecular orbital) catalysis approach for forming polycyclic frameworks.
Posted in Cascade Reactions, Methodology, Organocatalytic, Polycyclic, Ring forming, Unnatural Products | Leave a Comment »
Posted by naturalproductman on March 20, 2010
Thomas Paululat and co-workers at the University of Siegen in Germany have recently reported on the isolation of grecocycline B from Streptomyces sp. Acta 1362. The new polycyclic compound had an IC50 of 0.52 micromolar against tyrosine phosphatase B1. Interestingly, protein tyrosine phosphatase PTP1B is a target for the treatment of obesity, type 2 diabetes and cancer.
European JOC paper
Posted in Angucyclines, Aromatic, Diabetes Type 2, Diseases, Obesity, Polycyclic, SAR studies | Leave a Comment »
Posted by naturalproductman on March 19, 2010
Timothy Jamison and co-workers have recently published in JOC on a CsF mediated epoxide opening cascade of a polyepoxy molecule that has TMS substituents.
Posted in Cascade Reactions, Methodology, Polycyclic, Polyether, Polyketides | Leave a Comment »
Posted by naturalproductman on August 17, 2009
Elisapterosin F has recently been isolated by Abimael Rodriguez and co-worker at the University of Puerto Rico. Its structure says it all. They didn’t isolate enough to test any biological activities but from the previously isolated elisapterosins (D and E), these structures have anti-plasmodial activity (10 microgams/mL).
TL paper 2003 (Elisapterosins D and E)
Posted in Diterpene, Polycyclic | Leave a Comment »