Naturalproductman’s Blog

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Archive for the ‘Polyether’ Category

Gambieric acid A synthesis

Posted by naturalproductman on July 16, 2012

Makoto Sasaki and co-workers at Tohoku University have reported in JACS on the synthesis of gambieric acid A.

gambieric acid A

JACS paper

Posted in Cascade Reactions, Methodology, Polyether | Leave a Comment »

Gambierol analogs

Posted by naturalproductman on April 18, 2012

Luis Botana and co-workers from Universidad de Santiago de Compostela, Lugo, Spain have reported in JACS on the synthesis of gambierol analogs.

gambierol

JACS paper

Posted in Methodology, Polyether, Unnatural Products | Leave a Comment »

Brevisulcenal F

Posted by naturalproductman on February 29, 2012

Brevisulcenal F has been isolated from a dinoflagellate. Masayuki Satake and co-workers from the University of Tokyo have isolated and characterized this deadly compound, which killed many fish in New Zealand.

brevisulcenal

JACS paper

Posted in Cancer, Polyether | Leave a Comment »

Halichondrin C synthesis

Posted by naturalproductman on December 30, 2011

Yoshito Kishi and co-workers have reported in JACS on the synthesis of halichondrin C.

halichondrin C

JACS paper

Posted in Methodology, Polyether, Total Synthesis | Leave a Comment »

Oxiranyl anion cascade

Posted by naturalproductman on October 7, 2011

Yuji Mori and co-workers at Meijo University have reported in Organic Letters on an approach to tackle the synthesis of cyclic polyethers.

polyether

OL paper

Posted in Cascade Reactions, Methodology, Polyether | Leave a Comment »

Brevenal Synthesis

Posted by naturalproductman on February 15, 2011

Jon Rainier and co-workers at Utah have published in JACS on the total synthesis of brevenal.

brevenal

 

JACS paper

Posted in Cascade Reactions, Methodology, Polyether | 2 Comments »

Epoxide Opening Cascade

Posted by naturalproductman on March 19, 2010

Timothy Jamison and co-workers have recently published in JOC on a CsF mediated epoxide opening cascade of a polyepoxy molecule that has TMS substituents.

epoxide

JOC paper

Posted in Cascade Reactions, Methodology, Polycyclic, Polyether, Polyketides | Leave a Comment »

Halichondrin

Posted by naturalproductman on October 7, 2009

When an expert in total synthesis such as Kishi has a name on a journal article that is focused on synthesis of natural products, you know it has to be good.  The highlight of this synthesis is really the Ni/Cr catalyzed coupling using an aldehyde and a vinyl iodide.

halichondrin

h2

JACS paper 1

JACS paper 2

Posted in Asymmetric, cross coupling, Macrolides, Methodology, Polycyclic, Polyether, Transition Metal | Leave a Comment »

Cascade Polyepoxide Opening

Posted by naturalproductman on August 10, 2009

Timothy Jamison et. al have published in JACS on a cascade polyepoxide opening reaction to synthesize the 7,7,6-tricyclic ring system of dioxepandehydrothyrsiferol.

epoxide opening

JACS paper

Posted in Cascade Reactions, Methodology, Polyether, Ring forming | Leave a Comment »

Polyepoxide Openings to Make Poly-tetrahydropyrans

Posted by naturalproductman on May 14, 2009

Timothy Jamison at MIT has been working on this poly-epoxide cascade opening for a while in order to make these polycyclic rings.

polyepoxide opening

ACIEE paper

Posted in Cascade Reactions, Methodology, Polyether | Leave a Comment »

 
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