Naturalproductman’s Blog

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Archive for the ‘Polyketides’ Category

That’s a lot of alcohols…

Posted by naturalproductman on June 11, 2013

George O’Doherty and colleague at Northeastern University have reported in JACS on a synthesis of cryptocaryol.

 

JACS paper

Posted in Methodology, Polyketides | Leave a Comment »

Linoxepin synthesis

Posted by naturalproductman on April 18, 2013

Mark Lautens and co-workers at the University of Toronto have reported in ACIE on the synthesis of linoxepin.

linoxepin

ACIE paper

Posted in Aromatic, Polyketides, Total Synthesis | Leave a Comment »

Spongiastatin 2 synthesis

Posted by naturalproductman on March 8, 2013

Steven Ley and co-workers have reported in Chemical Science on the synthesis of spongiastatin 2.

spongiastatin 2

Chemical Science paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Puraquinonic acid synthesis

Posted by naturalproductman on February 20, 2013

James Gleason and co-workers from McGill University have reported in ACIE on the synthesis of puraquinonic acid. I didn’t know that Robert Ireland of University of Virginia died last year.

puraquinonic acid

ACIE paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Trichodermatide A synthesis

Posted by naturalproductman on February 20, 2013

Kou Hiroya and co-workers from Musashino University have reported in ACIE on the synthesis of trichodermatide A.

beast

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Citreoviripyrones A and B

Posted by naturalproductman on February 20, 2013

Teigo Asai and co-workers from Tohoku University have isolated some cyclobutane containing polyketides. They also treated a linear polyketide precursor, citreovirimontanin with a palladium catalyst to form the 6,4-bicycle.

polyketide

OL paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Spirangien A synthesis

Posted by naturalproductman on January 17, 2013

Mark Rizzacasa and co-workers from the University of Melbourne have reported in Organic Letters on their formal synthesis of spirangien A.

spirangien A

OL paper

Posted in Iron, Manganese, Metathesis, Methodology, Polyketides, Spiroketals, Transition Metal | Leave a Comment »

Lactonamycin synthesis

Posted by naturalproductman on January 16, 2013

Masaya Nakata and co-workers from Keio University have reported in ACIE on the synthesis of lactonamycin.

lactonamycin

ACIE paper

Posted in Methodology, Polyketides | Leave a Comment »

Calvicularin synthesis

Posted by naturalproductman on January 10, 2013

Christopher Beaudry and co-workers from Oregon State have reported in Organic Letters on a synthesis of cavicularin using a vinyl sulfone for a Diels-Alder substrate.

calvicularin

OL paper

Posted in Aromatic, Cascade Reactions, Diels-Alder, Methodology, Named Reactions, Polyketides | Leave a Comment »

Nahuoic acid A

Posted by naturalproductman on December 29, 2012

Raymond Andersen and co-workers from the University of British Columbia have reported in Organic Letters on the isolation of nahuoic acid A.

nahuoic acid A

OL paper

Posted in Histone-lysine N-methyltransferase SETD8, Polyketides, Protein Targets | Leave a Comment »

 
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