Naturalproductman’s Blog

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Archive for the ‘Polyketides’ Category

Rubromycin synthesis

Posted by naturalproductman on March 14, 2014

Hans-Ulrich Leissig and co-workers at Freie Universitat Berlin have reported in ACIE on the synthesis of rubromycin.

rubromycin

ACIE paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Secalonic acids A and D

Posted by naturalproductman on February 19, 2014

John Porco and colleague have reported in ACIE on the synthesis of secalonic acids A and D.

dimer

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Leiodermatolide synthesis

Posted by naturalproductman on February 19, 2014

Ian Patterson and co-workers have reported in ACIE on the synthesis of leiodermatolide.

synthesis

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Peloruside vs. Taxol

Posted by naturalproductman on January 30, 2014

Michel Steinmetz and co-workers from Paul Scherrer Institut in Switzerland have reported in ACIE on a crystal structure of peloruside bound to beta-tubulin. Interestingly, peloruside and taxol bind to beta-tubulin differently.

taxol

ACIE paper

Posted in Cancer, Crystal Structure, Polyketides | Leave a Comment »

Baulamycins

Posted by naturalproductman on January 17, 2014

David Sherman and co-workers found some new natural products with anti-biotic activities (IC50s ranging from low to high micromolar range) and reported this in JACS.
baulamycins

 

JACS paper

Posted in Antibiotics, Polyketides | Leave a Comment »

Vineomycin B2 synthesis

Posted by naturalproductman on October 11, 2013

Kazunobu Toshima and co-workers at Keio University have reported in JACS on a synthesis of vineomycin B2.

polyketide

JACS paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Merochlorin A synthesis

Posted by naturalproductman on September 27, 2013

Jonathan George and co-workers from the University of Adelaide have reported in ACIE on the synthesis of merochlorin A.

merochlorin A

ACIE paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Cavicularin synthesis

Posted by naturalproductman on August 23, 2013

Keisuke Suzuki and co-workers from the Tokyo Institute of Technology have reported in ACIE on the synthesis of cavicularin.

cavicularin

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Simaomicin synthesis

Posted by naturalproductman on August 23, 2013

Joseph Ready and co-workers at UT Southwestern have reported in ACIE on the synthesis of simaomicin.

simaomicin

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Viridicatumtoxin synthesis

Posted by naturalproductman on August 6, 2013

Nicolaou and co-workers at Rice University have reported in ACIE on the synthesis of viridicatumtoxin.

polyketide

ACIE paper

Posted in Cancer, Polyketides | Leave a Comment »

 
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