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Archive for the ‘Polyketides’ Category

Polyketide-peptide hybrid

Posted by naturalproductman on June 28, 2014

Liangcheng Du and co-workers at University of Nebraska-Lincoln have reported in ACIE on a polyketide synthase–nonribosomal peptide synthetase that made a hybrid polyketide-peptide compound.

polyketide

ACIE paper

Posted in Chemical Biology, Hybrids, Peptides, Polyketides | Leave a Comment »

Clusianone synthesis

Posted by naturalproductman on June 28, 2014

John Porco and colleague at Boston University have reported in ACIE on the synthesis of
clusianone

 

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Marinomycin A synthesis

Posted by naturalproductman on June 28, 2014

Susumi Hatakeyama and co-workers from Nagasaki University have reported in ACIE on the synthesis of marinomycin A.

marinomycin A

ACIE paper

Posted in C2-Symmetric, Methodology, Polyketides, Total Synthesis | Leave a Comment »

Polyketide dimerizing P450s

Posted by naturalproductman on April 18, 2014

Michael Muller and co-workers reported in JACS on the identification of some P450 enzymes involved in dimerizing polyketide natural products.

JACS paper

Posted in Biosynthesis, Polyketides | Leave a Comment »

Rubromycin synthesis

Posted by naturalproductman on March 14, 2014

Hans-Ulrich Leissig and co-workers at Freie Universitat Berlin have reported in ACIE on the synthesis of rubromycin.

rubromycin

ACIE paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Secalonic acids A and D

Posted by naturalproductman on February 19, 2014

John Porco and colleague have reported in ACIE on the synthesis of secalonic acids A and D.

dimer

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Leiodermatolide synthesis

Posted by naturalproductman on February 19, 2014

Ian Patterson and co-workers have reported in ACIE on the synthesis of leiodermatolide.

synthesis

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Peloruside vs. Taxol

Posted by naturalproductman on January 30, 2014

Michel Steinmetz and co-workers from Paul Scherrer Institut in Switzerland have reported in ACIE on a crystal structure of peloruside bound to beta-tubulin. Interestingly, peloruside and taxol bind to beta-tubulin differently.

taxol

ACIE paper

Posted in Cancer, Crystal Structure, Polyketides | Leave a Comment »

Baulamycins

Posted by naturalproductman on January 17, 2014

David Sherman and co-workers found some new natural products with anti-biotic activities (IC50s ranging from low to high micromolar range) and reported this in JACS.
baulamycins

 

JACS paper

Posted in Antibiotics, Polyketides | Leave a Comment »

Vineomycin B2 synthesis

Posted by naturalproductman on October 11, 2013

Kazunobu Toshima and co-workers at Keio University have reported in JACS on a synthesis of vineomycin B2.

polyketide

JACS paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

 
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