Naturalproductman’s Blog

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Archive for the ‘Polyketides’ Category

Forazoline A

Posted by naturalproductman on September 10, 2014

I thought I was going to have some down time before I posted again, but I ran into this interesting isolation paper of forazoline A that is worth a gander from Tim Bugni’s lab in the University of Wisconsin. They used a 15N-13C HMQC technique to determine which carbon was bonded to which nitrogen, which is apparently the first time this technique was used for a natural product. Looks like a pretty large natural product (m/z 901.4205). They have an interesting looking 13C NMR spectrum of the natural product (13C-labeled) that have splitting patterns on basically all of the carbons of the natural product (and thus looks like a proton NMR).

ACIE paper

Posted in Antifungal, New Setups, New Types, NMR, Polyketides, Polythio Compounds, Thiazoles | Leave a Comment »

Merochlorins A and B syntheses, enzymatically

Posted by naturalproductman on August 18, 2014

Bradley Moore and Phil Baran’s groups teamed up to synthesize merochlorin A and B.

Merochlorin

ACIE paper

Posted in Biosynthesis, Chemical Biology, Enzymatic, Polyketides, Total Synthesis | Leave a Comment »

Viridicatumtoxin B synthesis

Posted by naturalproductman on August 18, 2014

Nicolaou and co-workers have reported in JACS on the synthesis of viridicatumtoxin B.

polyketide

JACS paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Polyketide-peptide hybrid

Posted by naturalproductman on June 28, 2014

Liangcheng Du and co-workers at University of Nebraska-Lincoln have reported in ACIE on a polyketide synthase–nonribosomal peptide synthetase that made a hybrid polyketide-peptide compound.

polyketide

ACIE paper

Posted in Chemical Biology, Hybrids, Peptides, Polyketides | Leave a Comment »

Clusianone synthesis

Posted by naturalproductman on June 28, 2014

John Porco and colleague at Boston University have reported in ACIE on the synthesis of
clusianone

 

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Marinomycin A synthesis

Posted by naturalproductman on June 28, 2014

Susumi Hatakeyama and co-workers from Nagasaki University have reported in ACIE on the synthesis of marinomycin A.

marinomycin A

ACIE paper

Posted in C2-Symmetric, Methodology, Polyketides, Total Synthesis | Leave a Comment »

Polyketide dimerizing P450s

Posted by naturalproductman on April 18, 2014

Michael Muller and co-workers reported in JACS on the identification of some P450 enzymes involved in dimerizing polyketide natural products.

JACS paper

Posted in Biosynthesis, Polyketides | Leave a Comment »

Rubromycin synthesis

Posted by naturalproductman on March 14, 2014

Hans-Ulrich Leissig and co-workers at Freie Universitat Berlin have reported in ACIE on the synthesis of rubromycin.

rubromycin

ACIE paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Secalonic acids A and D

Posted by naturalproductman on February 19, 2014

John Porco and colleague have reported in ACIE on the synthesis of secalonic acids A and D.

dimer

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Leiodermatolide synthesis

Posted by naturalproductman on February 19, 2014

Ian Patterson and co-workers have reported in ACIE on the synthesis of leiodermatolide.

synthesis

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

 
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