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Archive for the ‘Polyketides’ Category

Tiacumicin B (Lipiarmycin A3/Fidaxomicin) aglycone synthesis

Posted by naturalproductman on December 15, 2014

Karl Heinz-Altmann and co-workers at ETH Zurich have reported in ACIE on the synthesis of fidaxomicin aglycone.

fidaxomicin

ACIE paper

Posted in Macrolides, Polyenes, Polyketides, Total Synthesis | Leave a Comment »

Leucosceptroids A and B syntheses

Posted by naturalproductman on December 6, 2014

Dawei Ma and co-workers have reported in ACIE on the synthesis of leucosceptroids A and B.

A and B

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Kushecarpin A synthesis

Posted by naturalproductman on December 6, 2014

Thomas Pettus and co-workers have reported in ACIE on the syntheses of some polyketides related to kushecarpin A.

kushecarpin A

ACIE paper

Posted in Polyketides, Total Synthesis, Unified | Leave a Comment »

Hippolachnin A synthesis

Posted by naturalproductman on December 6, 2014

Erick Carreira and co-workers have reported in ACIE on the synthesis of hippolachnin A.
synthesis
ACIE paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Cochliomycin synthesis via NHK

Posted by naturalproductman on November 29, 2014

Martin Banwell and co-workers at the Australian National University have reported in JOC on the synthesis of cochliomycins A and B.

cochliomycins

JOC paper

Posted in cross coupling, Macrolides, Metathesis, Methodology, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Lipiarmycin synthesis

Posted by naturalproductman on November 28, 2014

Jieping Zhu and co-workers at CNRS EPFL-SB-ISIC-LSPN have reported in ACIE on the synthesis of lipiarmycin.

polyketide

ACIE paper

Posted in Glycosides, Methodology, Polyketides, Total Synthesis | 2 Comments »

Mogolides A and B syntheses

Posted by naturalproductman on November 28, 2014

Yefeng Tang and co-workers from Tsinghua University have reported in ACIE on the synthesis mogolides A and B.

biomimetic

ACIE paper

Posted in Diels-Alder, Dimer, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Fidaxomicin synthesis

Posted by naturalproductman on November 28, 2014

Karl Gademann and co-workers at the University of Basel have reported in ACIE on the synthesis of
fidaxomicin
ACIE paper

Posted in Methodology, Named Reactions, Polyketides, Total Synthesis, Yamaguchi macrolactonization | Leave a Comment »

Apoptolidins localize in mitochondria

Posted by naturalproductman on November 28, 2014

Gary Sulikowski and co-workers at Vanderbilt University have reported in ACIE on the use of some fluorescent probe versions of apoptolidin natural products and determined that the natural product localizes in the mitochondria of cancer cells.

mitochondria

ACIE paper

Posted in Cancer, Chemical Biology, lung, Polyketides | Leave a Comment »

Gracilioether F synthesis

Posted by naturalproductman on November 4, 2014

Kevin Brown and co-workers at Indiana University have reported in ACIE on the synthesis of gracilioether F.

gracilioether F

ACIE paper

Posted in Cascade Reactions, Methodology, Polyketides, Total Synthesis | Leave a Comment »

 
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