Aculeatin, a polyspirocyclic natural product isolated from the rhizome, Amomun aculeatum, which is a plant that is used to treat malaria and fever in Papua, New Guinea, was isolated in 2000 and reported in Helv. Chim. Acta. by Heilman and co-workers (HCA link). Yung-Sing Wong and co-workers from Universite de Grenoble in France has published in Jounral of Medicinal Chemistry on some active analogues of this natural product in 2008 – with nanomolar activity against the protist, Plasmodium falciporum, which is responsible for malaria.