Naturalproductman’s Blog

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Archive for the ‘Polythio Compounds’ Category

Forazoline A

Posted by naturalproductman on September 10, 2014

I thought I was going to have some down time before I posted again, but I ran into this interesting isolation paper of forazoline A that is worth a gander from Tim Bugni’s lab in the University of Wisconsin. They used a 15N-13C HMQC technique to determine which carbon was bonded to which nitrogen, which is apparently the first time this technique was used for a natural product. Looks like a pretty large natural product (m/z 901.4205). They have an interesting looking 13C NMR spectrum of the natural product (13C-labeled) that have splitting patterns on basically all of the carbons of the natural product (and thus looks like a proton NMR).

ACIE paper

Posted in Antifungal, New Setups, New Types, NMR, Polyketides, Polythio Compounds, Thiazoles | Leave a Comment »

Sinulariaoid A

Posted by naturalproductman on August 20, 2014

Cui-Xian Zhang and co-workers from Guangzhou University have reported in Tetrahedron on a poly-sulfur lactone compound.

sulfur

Tetrahedron paper

Posted in Apoptosis, Cancer, Lactones, Polythio Compounds | Leave a Comment »

Gliocladin C synthesis

Posted by naturalproductman on March 1, 2013

Larry Overman and co-workers have reported in JACS on some syntheses of gliocladin C and some other dithio alkaloids.

dithio

JACS paper

Posted in Alkaloids, Methodology, Polythio Compounds, Total Synthesis | Leave a Comment »

Acetylaranotin synthesis

Posted by naturalproductman on November 19, 2012

Hidetoshi Tokuyama and co-workers at Tohoku University have published in ACIE on the synthesis of acetylaranotin.

acetylaranotin

ACIE paper

Posted in Alkaloids, Methodology, Polythio Compounds, Total Synthesis | Leave a Comment »

Bacteria talking to algae

Posted by naturalproductman on October 25, 2011

Jon Clardy and co-workers at Harvard have reported in JACS on some new molecules isolated from bacteria.

roseobacticides

JACS paper

Posted in Alkaloids, Indoles, Polythio Compounds | Leave a Comment »

Thailandespins

Posted by naturalproductman on October 14, 2011

Yi-Qiang Cheng and co-workers from the University of Wisconsin in Milwaukee have reported in the Journal of Natural Products on some disulfide compounds that have HDAC inhibitory activity – the compounds with the reduced disulfide bond was shown to be more active than the oxidized dithiol form.

disulfide bond

JNP paper

Posted in Cancer, Peptides, Polythio Compounds | Leave a Comment »

Gliotoxin metabolites using DANS

Posted by naturalproductman on June 6, 2011

Frank Schroeder and co-workers at Cornell have reported in JACS on the isolation of gli dependent metabolites using differential analysis by 2D NMR spectroscopy (DANS).
gliotoxin

JACS paper

Posted in Chemical Biology, New Setups, Polythio Compounds | Leave a Comment »

Epicoccin G synthesis

Posted by naturalproductman on May 12, 2011

Nicolaou and co-workers have reported in JACS on their total synthesis of epicoccin G using a Kornblum-DeLaMare rearrangement to access the gamma-hydroxy ketone.

epicoccin
JACS paper

Posted in Cascade Reactions, Kornblum-DeLaMare rearrangement, Methodology, Named Reactions, Polythio Compounds | Leave a Comment »

Gliocladine C Synthesis

Posted by naturalproductman on April 8, 2011

Larry Overman and co-workers have reported in JACS on the total synthesis of gliocladine C the disulfide was introduced by using H2S.
gliocladine

JACS paper

Posted in Alkaloids, Cascade Reactions, Methodology, Polythio Compounds, Transition Metal | Leave a Comment »

Grassypeptolides

Posted by naturalproductman on November 5, 2010

Hendrik Luesch and co-workers from the University of Florida have published in JOC on the isolation and biological activities of grassypeptolides.  Grassypeptolide C had 44.6 nM IC50 against HeLa cells.

grassypeptolide

JOC paper

Posted in Peptides, Polythio Compounds | 1 Comment »

 
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