Gliocladin C synthesis

Larry Overman and co-workers have reported in JACS on some syntheses of gliocladin C and some other dithio alkaloids.

JACS paper

Acetylaranotin synthesis

Hidetoshi Tokuyama and co-workers at Tohoku University have published in ACIE on the synthesis of acetylaranotin.

ACIE paper

Bacteria talking to algae

Jon Clardy and co-workers at Harvard have reported in JACS on some new molecules isolated from bacteria.

JACS paper

Thailandespins

Yi-Qiang Cheng and co-workers from the University of Wisconsin in Milwaukee have reported in the Journal of Natural Products on some disulfide compounds that have HDAC inhibitory activity – the compounds with the reduced disulfide bond was shown to be more active than the oxidized dithiol form.

JNP paper

Gliotoxin metabolites using DANS

Frank Schroeder and co-workers at Cornell have reported in JACS on the isolation of gli dependent metabolites using differential analysis by 2D NMR spectroscopy (DANS).

JACS paper

Epicoccin G synthesis

Nicolaou and co-workers have reported in JACS on their total synthesis of epicoccin G using a Kornblum-DeLaMare rearrangement to access the gamma-hydroxy ketone.

JACS paper

Gliocladine C Synthesis

Larry Overman and co-workers have reported in JACS on the total synthesis of gliocladine C the disulfide was introduced by using H2S.

JACS paper

Grassypeptolides

Hendrik Luesch and co-workers from the University of Florida have published in JOC on the isolation and biological activities of grassypeptolides.  Grassypeptolide C had 44.6 nM IC50 against HeLa cells.

JOC paper

Hoiamides

William Gerwick and co-workers have published on their studies of hoiamides, which may be a target for voltage gate sodium channels (VGSC).  This channel is a target for the treatment of neurodegenerative disorders – there are neurotoxin sites (at least seven) on VGSCs that are targeted by drugs.

JNP paper

Onionin A

Toshihiro Nohara and co-workers at Sojo University in Japan have published in the Journal of Natural Products on the isolation of onionin A and yes, it’s from a simple onion.  I have heard before that onions are good for you and this compound that is found in onions could be one of the reasons why they are good for our bodies.  The Nohara group in Japan isolated a tetrahydrothiophene oxide compound and found that it had suppressed the expression of CD163 at 10 and 30 micromolar concentrations.  This inhibition suggests that onionin A inhibits the polarization of M2 alternatively activated macrophages, which in turn inhibits tumor cell proliferation.

JNP paper