Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Protein Targets’ Category

Swinhoeisterol

Posted by naturalproductman on April 3, 2014

Wen Zhang and co-workers from Second Military Medical University in China have reported in Organic Letters on the isolation of swinhoeisterol.
swinhoeisterol

OL paper

Posted in Protein Targets, Seven-Membered Rings, Steroids | Leave a Comment »

Bcl-XL and Bcl-2 interaction

Posted by naturalproductman on April 5, 2013

Thorsten Berg and co-workers at the University of Leipzig have reported in ACIE on the study of some small molecules disrupting the interaction of Bcl-XL and Bcl-2.

apoptosis

ACIE paper

Posted in Protein Targets, Proteins, Receptors | Leave a Comment »

Vegfrecine

Posted by naturalproductman on February 22, 2013

Hayamitsu Adachi and co-workers from BIKAKEN have reported in JNP on a novel VEGF receptor tyrosine kinase inhibitor from bacteria. The only problem I see with this compound – from a toxicologist’s perspective – is that this is a quinone, and thus a very reactive electrophile. If this kind of functional group is used as a drug, who knows what other things it will react with in the body – be it DNA, proteins, etc…
vegfrecine

JNP paper

Posted in Alkaloids, Enzymes, Protein Targets, Proteins | Leave a Comment »

Asperterpenoid A

Posted by naturalproductman on January 31, 2013

Zhigang She and co-workers from Sun-Yat Sen University have reported in Organic Letters on the isolation of asperterpenoid A, which had an IC50 value of 2.2 micromolar against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB).

ABCDE

OL paper

Posted in Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Terpenoids | Leave a Comment »

Siladenoserinols

Posted by naturalproductman on December 29, 2012

Sachiko Tsukamoto and co-workers from Kumamoto University have reported in Organic Letters on the isolation of siladenoserinols A-L, which had inhibitory activity against p53 and HDM2 interaction.

interaction

OL paper

Posted in Cancer, p53, Protein Targets | Leave a Comment »

Nahuoic acid A

Posted by naturalproductman on December 29, 2012

Raymond Andersen and co-workers from the University of British Columbia have reported in Organic Letters on the isolation of nahuoic acid A.

nahuoic acid A

OL paper

Posted in Histone-lysine N-methyltransferase SETD8, Polyketides, Protein Targets | Leave a Comment »

Methyl sarcotroates

Posted by naturalproductman on December 29, 2012

Yue-Wei Guo and co-workers at the Chinese Academy of Sciences have reported in Organic Letters on the isolation of some diterpenoids.

PTPB1

OL paper

Posted in Diterpenoids, Protein Targets, protein tyrosine phosphatase 1B (PTP1B) | Leave a Comment »

Aplyronine A target

Posted by naturalproductman on December 11, 2012

Hideo Kigoshi and co-workers from the University of Tsukuba have reported in JACS on a chemical biological approach to find the aplyronine A target.

aplyronine A

JACS paper

 

Posted in Chemical Biology, Macrolides, Methodology, Protein Targets | Leave a Comment »

Tubulexin chemical biology

Posted by naturalproductman on October 25, 2012

Herbert Waldmann and co-workers at Max Planck have reported in ACIE on the chemical biology of tubulexins.

tubulexins

ACIE paper

Posted in Cancer, Chemical Biology, Methodology, Protein Targets, Unnatural Products | Leave a Comment »

Type 2 diabetes therapeutic?

Posted by naturalproductman on October 23, 2012

Here’s a study by Zhong-Yin Zhang and co-workers at Indiana University on a PTP-MEG2 inhibitor.

diabetes 2

JACS paper

Posted in Chemical Biology, Diabetes Type 2, Diseases, Methodology, Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Proteins | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 66 other followers