Thorsten Berg and co-workers at the University of Leipzig have reported in ACIE on the study of some small molecules disrupting the interaction of Bcl-XL and Bcl-2.
Archive for the ‘Protein Targets’ Category
Bcl-XL and Bcl-2 interaction
Posted by naturalproductman on April 5, 2013
Posted in Protein Targets, Proteins, Receptors | Leave a Comment »
Vegfrecine
Posted by naturalproductman on February 22, 2013
Hayamitsu Adachi and co-workers from BIKAKEN have reported in JNP on a novel VEGF receptor tyrosine kinase inhibitor from bacteria. The only problem I see with this compound – from a toxicologist’s perspective – is that this is a quinone, and thus a very reactive electrophile. If this kind of functional group is used as a drug, who knows what other things it will react with in the body – be it DNA, proteins, etc…
Posted in Alkaloids, Enzymes, Protein Targets, Proteins | Leave a Comment »
Asperterpenoid A
Posted by naturalproductman on January 31, 2013
Zhigang She and co-workers from Sun-Yat Sen University have reported in Organic Letters on the isolation of asperterpenoid A, which had an IC50 value of 2.2 micromolar against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB).
Posted in Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Terpenoids | Leave a Comment »
Siladenoserinols
Posted by naturalproductman on December 29, 2012
Sachiko Tsukamoto and co-workers from Kumamoto University have reported in Organic Letters on the isolation of siladenoserinols A-L, which had inhibitory activity against p53 and HDM2 interaction.
Posted in Cancer, p53, Protein Targets | Leave a Comment »
Nahuoic acid A
Posted by naturalproductman on December 29, 2012
Raymond Andersen and co-workers from the University of British Columbia have reported in Organic Letters on the isolation of nahuoic acid A.
Posted in Histone-lysine N-methyltransferase SETD8, Polyketides, Protein Targets | Leave a Comment »
Methyl sarcotroates
Posted by naturalproductman on December 29, 2012
Yue-Wei Guo and co-workers at the Chinese Academy of Sciences have reported in Organic Letters on the isolation of some diterpenoids.
Posted in Diterpenoids, Protein Targets, protein tyrosine phosphatase 1B (PTP1B) | Leave a Comment »
Aplyronine A target
Posted by naturalproductman on December 11, 2012
Hideo Kigoshi and co-workers from the University of Tsukuba have reported in JACS on a chemical biological approach to find the aplyronine A target.
Posted in Chemical Biology, Macrolides, Methodology, Protein Targets | Leave a Comment »
Tubulexin chemical biology
Posted by naturalproductman on October 25, 2012
Herbert Waldmann and co-workers at Max Planck have reported in ACIE on the chemical biology of tubulexins.
Posted in Cancer, Chemical Biology, Methodology, Protein Targets, Unnatural Products | Leave a Comment »
Type 2 diabetes therapeutic?
Posted by naturalproductman on October 23, 2012
Here’s a study by Zhong-Yin Zhang and co-workers at Indiana University on a PTP-MEG2 inhibitor.
Posted in Chemical Biology, Diabetes Type 2, Diseases, Methodology, Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Proteins | Leave a Comment »
Psoromic acid inhibits RabGGTase
Posted by naturalproductman on April 23, 2012
Yao-Wen Wu and co-workers at Max Planck have reported in JACS on the inhibition of RabGGTase using psoromic acid.
Posted in Aromatic, Cancer, Carboxylic acids, Post-Translational Modification, Protein Targets | Leave a Comment »
