Zhigang She and co-workers from Sun-Yat Sen University have reported in Organic Letters on the isolation of asperterpenoid A, which had an IC50 value of 2.2 micromolar against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB).
Archive for the ‘protein tyrosine phosphatase 1B (PTP1B)’ Category
Asperterpenoid A
Posted by naturalproductman on January 31, 2013
Posted in Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Terpenoids | Leave a Comment »
Methyl sarcotroates
Posted by naturalproductman on December 29, 2012
Yue-Wei Guo and co-workers at the Chinese Academy of Sciences have reported in Organic Letters on the isolation of some diterpenoids.
Posted in Diterpenoids, Protein Targets, protein tyrosine phosphatase 1B (PTP1B) | Leave a Comment »
Type 2 diabetes therapeutic?
Posted by naturalproductman on October 23, 2012
Here’s a study by Zhong-Yin Zhang and co-workers at Indiana University on a PTP-MEG2 inhibitor.
Posted in Chemical Biology, Diabetes Type 2, Diseases, Methodology, Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Proteins | Leave a Comment »
Dysidavarones
Posted by naturalproductman on December 2, 2011
Hou-Wen Lin and co-workers at Second Military Medical University have reported in Organic Letters on the isolation of dysidavarones A-D. Dysidavarones A and B had IC50 values of 9.98 and 21.6 μM towards protein
tyrosine phosphatase 1B (PTP1B).
Posted in Cancer, Enzymes, Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Proteins, Quinones, Sesquiterpenes | Leave a Comment »
