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Archive for the ‘protein tyrosine phosphatase 1B (PTP1B)’ Category

Asperterpenoid A

Posted by naturalproductman on January 31, 2013

Zhigang She and co-workers from Sun-Yat Sen University have reported in Organic Letters on the isolation of asperterpenoid A, which had an IC50 value of 2.2 micromolar against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB).

ABCDE

OL paper

Posted in Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Terpenoids | Leave a Comment »

Methyl sarcotroates

Posted by naturalproductman on December 29, 2012

Yue-Wei Guo and co-workers at the Chinese Academy of Sciences have reported in Organic Letters on the isolation of some diterpenoids.

PTPB1

OL paper

Posted in Diterpenoids, Protein Targets, protein tyrosine phosphatase 1B (PTP1B) | Leave a Comment »

Type 2 diabetes therapeutic?

Posted by naturalproductman on October 23, 2012

Here’s a study by Zhong-Yin Zhang and co-workers at Indiana University on a PTP-MEG2 inhibitor.

diabetes 2

JACS paper

Posted in Chemical Biology, Diabetes Type 2, Diseases, Methodology, Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Proteins | Leave a Comment »

Dysidavarones

Posted by naturalproductman on December 2, 2011

Hou-Wen Lin and co-workers at Second Military Medical University have reported in Organic Letters on the isolation of dysidavarones A-D.  Dysidavarones A and B had IC50 values of 9.98 and 21.6 μM towards protein
tyrosine phosphatase 1B (PTP1B).

PTP

OL paper

Posted in Cancer, Enzymes, Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Proteins, Quinones, Sesquiterpenes | Leave a Comment »

 
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