Danishefsky and co-workers reported in Science on the synthesis of erythropoietin after 1000 steps. Just kidding.
Archive for the ‘Proteins’ Category
Posted by naturalproductman on December 13, 2013
Posted by naturalproductman on April 5, 2013
Thorsten Berg and co-workers at the University of Leipzig have reported in ACIE on the study of some small molecules disrupting the interaction of Bcl-XL and Bcl-2.
Posted by naturalproductman on February 22, 2013
Hayamitsu Adachi and co-workers from BIKAKEN have reported in JNP on a novel VEGF receptor tyrosine kinase inhibitor from bacteria. The only problem I see with this compound – from a toxicologist’s perspective – is that this is a quinone, and thus a very reactive electrophile. If this kind of functional group is used as a drug, who knows what other things it will react with in the body – be it DNA, proteins, etc…
Posted by naturalproductman on January 17, 2013
Hideaki Oikawa and co-workers from Hokkaido University have reported in Organic Letters on the isolation of an enzyme that was known to produce some natural products. They expressed and purified the enzyme, incubated the enzyme in the presence of substrates: geranyl diphosphate (GPP) and isopentenyl diphosphate (IPP), and examined the products.
Posted by naturalproductman on November 19, 2012
Karen Anderson and co-workers at Yale have reported in JACS on a crystal structures of HIV-1 reverse transcriptase with catechol diether drugs.
Posted by naturalproductman on October 23, 2012
Here’s a study by Zhong-Yin Zhang and co-workers at Indiana University on a PTP-MEG2 inhibitor.
Posted by naturalproductman on April 18, 2012
I just wanted to highlight a C and E News article on some new drug candidates disclosed by drug companies…CEN article
In a nut shell:
Lexicon Pharmaceuticals on a diabetes type 2 drug – SGLT2 transporter inhibitor (JMC paper)
Gilead on an anti-inflammatory drug – TLR7 agonist (PNAS paper)
GlaxoSmithKline on a PI3K inhibitor for cancer treatment (Nature Medicine paper)
Bristol-Myers Squibb on a drug for migraine treatment – CGRP antagonist (ACSML paper)
Posted by naturalproductman on March 30, 2012
Nobuyoshi Akimitsu and co-workers from the University of Tokyo have reported on the identification of manoalide A as an inhibitor for heptatitis C virus NS3 helicase.
Posted by naturalproductman on March 2, 2012
Milton Stubbs and co-workers have reported in ACIEE on
Posted by naturalproductman on February 17, 2012
Andrew Bennet and co-workers from Simon Fraser University have reported in JACS on a transition state study of a sialidase enzyme.