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Archive for the ‘Sesquiterpenes’ Category

Transtaganolide syntheses

Posted by naturalproductman on May 17, 2013

Brian Stoltz and co-workers have reported in ACIE on the syntheses of transtaganolides through an Ireland-Claisen rearrangement/Diels-Alder cascade.

ICR/DA

ACIE paper

Posted in Asymmetric, Cascade Reactions, Claisen rearrangement, Diels-Alder, Methodology, Named Reactions, Sesquiterpenes, Total Synthesis | Leave a Comment »

Structural reassignment of aquatolide using DFT/NMR

Posted by naturalproductman on November 6, 2012

Dean Tantillo and co-workers have used Gaussian in conjunction with NMR and crystallography to reassign the structure of aquatolide.

structural reassignment

JACS paper

Posted in Computational, DFT, Lactones, Sesquiterpenes | Leave a Comment »

A 5,6,4-tricycle

Posted by naturalproductman on September 7, 2012

Ji-Kai Liu and co-workers from the Kunming Institute of Botany have reported in Organic Letters on the isolation of trefolane.

5,6,4

OL paper

Posted in Sesquiterpenes | Leave a Comment »

Chlorinated englerins

Posted by naturalproductman on February 10, 2012

John Beutler and co-workers from the NCI have reported in the Journal of Natural Products on the isolation of chlorinated englerins and their anti-cancer activities.

chlorinated

JNP paper

Posted in Cancer, renal, Sesquiterpenes, Sesquiterpenoids | Leave a Comment »

Artemisinin chemistry

Posted by naturalproductman on January 17, 2012

Giancarlo Marconi and co-workers have reported in Tetrahedron Letters on a reduction of artemisinin, an antimalarial compound, to break down the peroxide bond and open the ring.

artemisinin

TL paper

Posted in Diseases, Lactones, Malaria, Mechanistic, Sesquiterpenes | Leave a Comment »

Dysidavarones

Posted by naturalproductman on December 2, 2011

Hou-Wen Lin and co-workers at Second Military Medical University have reported in Organic Letters on the isolation of dysidavarones A-D.  Dysidavarones A and B had IC50 values of 9.98 and 21.6 μM towards protein
tyrosine phosphatase 1B (PTP1B).

PTP

OL paper

Posted in Cancer, Enzymes, Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Proteins, Quinones, Sesquiterpenes | Leave a Comment »

Africanan-1alpha-ol synthesis

Posted by naturalproductman on November 11, 2011

Douglass Taber and co-workers from the University of Delaware have reported in JOC on the synthesis of trans-africanan-1alpha-ol. The synthesis of the seven membered ring was achieved from a relay-ring closing metathesis reaction.  The synthesized structure does not seem to match the reported structure.

seven

JOC paper

Posted in Asthma, Cascade Reactions, Diseases, Metathesis, Methodology, Ruthenium, Sesquiterpenes, Seven-Membered Rings, Structural Reassignment, Total Synthesis, Transition Metal | Leave a Comment »

Perovskone synthesis

Posted by naturalproductman on October 5, 2011

George Majetich and co-workers at the University of Georgia have reported in Tetrahedron on the synthesis of perovskone.

cyclization

Tetrahedron paper

Posted in Cascade Reactions, Methodology, Sesquiterpenes | Leave a Comment »

Przewalskin B synthesis

Posted by naturalproductman on July 27, 2011

Yong-Qiang Tu and co-workers from Lanzhou University have reported in JOC on their synthesis of przewalskin B.

przewalskin B

JOC paper

Posted in Carbene, Methodology, Sesquiterpenes, Total Synthesis | Leave a Comment »

Axisonitrile

Posted by naturalproductman on July 3, 2011

Hunsa Prawat and co-workers from Chulabhorn Research Institute have reported in Tetrahedron on the isolation of axisonitrile.

sesquiterpene

Tetrahedron paper

Posted in Sesquiterpenes | Leave a Comment »

 
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