Englerin synthesis

Susumi Hatakeyama and co-workers at Nagasaki University have reported in JOC on the synthesis of englerin.

JOC paper

Presilphiperfolan-1-ol synthesis

Stoltz and colleague have reported in ACIE on the enantioselective syntheses of some sesquiterpenoid biosynthetic precursors.  The 5,6-ring system was made from an intramolecular Diels-Alder.

ACIE paper

A Heck reaction for a seven membered ring

Silas Cook and colleague at Indiana University have reported in Organic Letters on a formal synthesis of englerin.

OL paper

Englerin A formal synthesis

Kathlynn Parker and colleague have reported in Organic Letters on a formal synthesis of englerin A.

OL paper

Chlorinated englerins

John Beutler and co-workers from the NCI have reported in the Journal of Natural Products on the isolation of chlorinated englerins and their anti-cancer activities.

JNP paper

Tormesol via Wittig

Dongjoo Lee and co-workers at Dankook University have reported in Tetrahedron on the synthesis of tormesol.  The seven membered ring was acquired from a Horner-Wadsworth-Emmons reaction.

Tetrahedron paper

Compounds from a fungus

Nicholas Oberlies and co-workers at UNC Greensboro have reported in the Journal of Natural Products on the isolation of some peptides and sesquiterpenoids from the terrestrial filamentous fungus, Trichothecium sp.

JNP paper

Ophiobolin synthesis

Masahisa Nakada and co-workers have reported in ACIEE on a synthesis of ophiobolin where the seven membered ring was accessed via a ring closing metathesis.

ACIEE paper

Menelloides A and B

Ping-Jyun Sung and co-workers from National Dong Hwa University have reported in Tetrahedron on the isolation of some sesquiterpenoids from a coral.  They tested these compounds against superoxide anion generation by human neutrophils because the organic extracts of the Menella sp. had this activity, however the compounds had weak inhibitory effects towards this activity.

Tetrahedron paper

Rippertenol synthesis

Scott Snyder and co-workers have reported in JACS on their synthesis of rippertenol.

JACS paper