Asperterpenoid A

Zhigang She and co-workers from Sun-Yat Sen University have reported in Organic Letters on the isolation of asperterpenoid A, which had an IC50 value of 2.2 micromolar against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB).

OL paper

Amphilectene synthesis

Ryan Shenvi and colleague at Scripps have reported in JACS on the synthesis of amphilectene, an antimalarial compound.

JACS paper

Indium bromide cyclization

Teck-Peng Loh and co-workers from the University of Science and Technology have reported in ACIE on the synthesis of moluccanic acid methyl ester through a Prins-polyene cyclization using indium (III) bromide.

ACIE paper

FR182877 progress

Masahisa Nakada and co-workers from Waseda University have reported in Organic Letters on their progress towards FR182877.

OL paper

Vigulariol and sclerophytin A syntheses

Michael Crimmins and co-workers at UNC have reported in Organic Letters on the syntheses of two similar looking natural products, vigulariol and sclerophytin A.

OL paper

Sterostreins

Terpenoids were isolated from a fungus called sterostreins A-E, which had antimalarial activity (IC50 2.3 micrograms/mL).

OL paper

Dotofide

Gabriele Konig and co-workers have reported in the European Journal of Organic Chemistry on the isolation of a terpenoid from a sea slug.

European JOC paper

Breviones syntheses

Kozo Shishido and co-workers from the University of Tokushima have reported in JACS on their syntheses of breviones.

JACS paper

Callicarpenal Synthesis

Emmanuel Theodorakis and co-workers at UCSD have reported in Tetrahedron on the synthesis of a bug repellent isolated from Callicarpa americana.

 

Tetrahedron paper

DFT with NMR

Alessandro Bagno and co-workers at Universitat Padova have reported in JACS on the use of density functional theory and NMR to assign the stereochemistry to vannusal B.

 

JACS paper