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Archive for the ‘Total Synthesis’ Category

Leiodermatolide synthesis

Posted by naturalproductman on October 28, 2014

Furstner and colleagues have reported in JACS on the synthesis of leiodermatolide.

leiodermatolide

JACS paper

Posted in Cancer, P-glycoprotein, Protein Targets, Total Synthesis | Leave a Comment »

Synthesis of 6-Deoxypladienolide D, which binds to SF3B1

Posted by naturalproductman on October 28, 2014

Gregg Keaney and co-workers at H3 Biomedicine have reported in Org Lett on the synthesis of 6-deoxypladienolide D.
6-deoxypladienolide D

OL paper

Posted in Named Reactions, Polyketides, Suzuki-Miyaura, Total Synthesis | 1 Comment »

Paracaseolide A synthesis

Posted by naturalproductman on October 25, 2014

Goverdhan Mehta (University of Hyderabad) and co-workers at IIT Hyderabad have reported in Tetrahedron on the synthesis of paracaseolide A.
paracaseolide A

Tetrahedron paper

Posted in Diels-Alder, Named Reactions, Total Synthesis | Leave a Comment »

Axinellamines A and B

Posted by naturalproductman on October 25, 2014

When I saw the abstract figure, I wasn’t surprised to see that this paper came from Phil Baran’s group.

axinellamines

JACS paper

Posted in Alkaloids, Methodology, Total Synthesis | Leave a Comment »

Haouamine B pentaacetate synthesis

Posted by naturalproductman on October 11, 2014

Hidetoshi Tokuyama and co-workers from Tohoku University have reported in ACIE on the synthesis of haouamine B pentaacetate.

haouamine B

ACIE paper

Posted in Alkaloids, Structural Reassignment, Total Synthesis | Leave a Comment »

Hapalindole alkaoid syntheses

Posted by naturalproductman on October 11, 2014

Ang Li and co-workers from SIOC have reported in ACIE on the syntheses of hapalindole compounds.

hapalindole

ACIE paper

Posted in Alkaloids, Indoles, Total Synthesis | Leave a Comment »

Δ9-THC synthesis

Posted by naturalproductman on October 11, 2014

Erick Carreira and co-workers have reported in ACIE on the synthesis of dehydrotetrahydrocannabinol.

THC

ACIE paper

Posted in Dual Catalysis, Methodology, Total Synthesis | Leave a Comment »

N-methylwelwitindolinone B isothiocyanate synthesis

Posted by naturalproductman on October 11, 2014

Neil Garg and co-workers reported the synthesis of N-methylwelwitindolinone B isothiocyanate in JACS.

alkaloid

JACS paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Unified strategies are in

Posted by naturalproductman on October 7, 2014

Jieping Zhu and co-workers from CNRS have reported in JACS on the syntheses of some alkaloids, goniomitine, 1,2-dehydroaspidospermidine, aspidospermidine, vincadifformine, and kopsihainanine A.

 

JACS paper

Posted in Alkaloids, Indoles, Total Synthesis | Leave a Comment »

Rakicidin A synthesis

Posted by naturalproductman on October 7, 2014

Yue Chen and co-workers from Nankai University have reported in JACS on the synthesis of rakicidin A, which has inhibitory activity towards cancer stem cells.

 

 

JACS paper

Posted in Macrocycles, Total Synthesis | Leave a Comment »

 
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