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Archive for the ‘Total Synthesis’ Category

Aspeverin synthesis

Posted by naturalproductman on August 30, 2014

Adam Levinson at Sloan Kettering has reported in Organic Letters on the synthesis of aspeverin. Interestingly, Danishefsky was acknowledged for the mentorship but not included in the authors list. I wonder if this is a new kind of way to publish.

aspeverin

OL paper

Posted in Alkaloids, Hypervalent Iodine, Methodology, Total Synthesis | 3 Comments »

Steviol, hetidine, isoatisine syntheses

Posted by naturalproductman on August 30, 2014

Phil Baran and co-workers have reported in JACS on the syntheses of steviol, hetidine, and isoatisine.

alkaloids

JACS paper

Posted in Alkaloids, C-H activation, Methodology, Total Synthesis | Leave a Comment »

Basiliolide B synthesis

Posted by naturalproductman on August 30, 2014

Chi-Sing Lee and co-workers at Shen Zhen University have reported in ACIE on the synthesis of basioli
basiliolide B

ACIE paper

Posted in Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Myceliothermophins C, D, and E

Posted by naturalproductman on August 30, 2014

Nicolaou and co-workers have reported in ACIE on the syntheses of myceliothermophins C, D, and E.

myceliothermophins

ACIE paper

Posted in Methodology, Total Synthesis | Leave a Comment »

Cyclobutenone ring expansion

Posted by naturalproductman on August 20, 2014

Guangbin Dong and colleague at UT Austin have reported in ACIE on the synthesis of cycloinumakiol through a rhodium catalyzed cascade reaction that forms the tetracyclic ring structure of the compound.

C-C

ACIE paper

Posted in Methodology, One pot, Rhodium, Ring expansion, Ring forming, Ring Opening, Total Synthesis, Transition Metal | Leave a Comment »

Gymnothelignan N synthesis

Posted by naturalproductman on August 18, 2014

Xuegong She and co-workers from Lanzhou University have reported in Organic Letters on the synthesis of

Friedel-Crafts

OL paper

Posted in Friedel-Crafts, Named Reactions, Spirocycles, Spirocyclic centers, Total Synthesis | Leave a Comment »

(+)-Procyanidin A2 and (+)-Cinnamtannin B1 syntheses

Posted by naturalproductman on August 18, 2014

Keisuke Suzuki and co-workers from Tokyo Institute of Technology have reported in ACIE on the synthesis of (+)-procyanidin A2 and (+)-cinnamtannin B1.

aromatic

ACIE paper

Posted in Aromatic, Total Synthesis | Leave a Comment »

Merochlorins A and B syntheses, enzymatically

Posted by naturalproductman on August 18, 2014

Bradley Moore and Phil Baran’s groups teamed up to synthesize merochlorin A and B.

Merochlorin

ACIE paper

Posted in Biosynthesis, Chemical Biology, Enzymatic, Polyketides, Total Synthesis | Leave a Comment »

Delta12-prostaglandin J3 synthesis

Posted by naturalproductman on August 18, 2014

Nicolaou and co-workers have reported in ACIE on the synthesis of delta12-prostaglandin J3.

prostaglandin J3

ACIE paper

Posted in Aldol, Cancer, leukemia, Methodology, Polyenes, Prostaglandins, Total Synthesis | Leave a Comment »

Cavicularin synthesis

Posted by naturalproductman on August 18, 2014

Christopher Beaudry and colleague at Oregon State have reported in ACIE on the synthesis of cavicularin through a Diels-Alder with a vinyl sulfone dienophile.

Diels Alder

ACIE paper

Posted in Aromatic, Diels-Alder, Methodology, Total Synthesis | Leave a Comment »

 
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