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Archive for the ‘Triterpenoids’ Category

Guttiferone A synthesis

Posted by naturalproductman on March 7, 2014

Bernd Plietker and co-workers at Universitat Stuttgart reported in JACS on the synthesis of guttiferone A.

guttiferone A

JACS paper

Posted in Methodology, Total Synthesis, Triterpenoids | 1 Comment »

Merrilactone synthesis

Posted by naturalproductman on May 5, 2012

Hongbin Zhai and co-workers at the Chinese Academy of Sciences have published in ACIE on the synthesis of merrilactone where they used a Pauson-Khand reaction as one of the key steps.

Pauson-Khand

ACIE paper

Posted in Cascade Reactions, Johnson Claisen rearrangement, Methodology, Named Reactions, Neurodegenerative, Pauson-Khand, Triterpenoids | Leave a Comment »

(8R)-3β,8-Dihydroxypolypoda-13E,17E,21-triene

Posted by naturalproductman on August 10, 2011

Thomas Simmet and co-workers from Ulm University have reported in the Journal of Natural Products on the isolation of (8R)-3β,8-Dihydroxypolypoda-13E,17E,21-triene from the oleogum resin of P. lentiscus.  This compound had inhibitory activity against androgen-insensitive prostate cancers (~10 micromolar).

prostate

JNP paper

Posted in Cancer, prostate, Triterpenoids, Trophy Targets | Leave a Comment »

This molecule is pretty

Posted by naturalproductman on May 25, 2011

Keiji Tanino and co-workers from Hokkaido University have reported in Nature Chemistry on the synthesis of solanoeclepin A – this molecule is similar to glycinoeclepin in activity and structure…the biological activity is related to dafachronic acid where it stimulates the hatching of nematodes.

solanoeclepin A

Nature Chemistry paper Read the rest of this entry »

Posted in Cascade Reactions, Cycloaddition, Methodology, Pericyclic reactions, Triterpenoids | Leave a Comment »

Machilusides

Posted by naturalproductman on May 6, 2011

Jiangong Shi and co-workers at the Chinese Academy of Medical Sciences have reported in Organic Letters on the isolation of machilusides.

machilusides

OL paper

Posted in Cancer, Glycosides, Triterpenoids | Leave a Comment »

Duboscic acid

Posted by naturalproductman on November 22, 2010

Pascal Wafo and co-workers from France have published in Organic Letters on the isolation of duboscic acid.  It had alpha-glucosidase inhibition activity with with an IC50 value of 100 ± 8.1 μM.  So you might wonder why alpha-glucosidase inhibition is important – alpha-glucosidase is an enzyme that hydrolyzes disaccharides into monosaccharides so the inhibition of this enzyme should slow down the absorption of glucose in people, which is especially important in diabetic patients.

triterpenoid

 

OL paper

Posted in Diabetes Type 2, Diseases, Seven-Membered Rings, Triterpenoids | Leave a Comment »

Esculeoside A

Posted by naturalproductman on September 24, 2010

Toshihiro Nohara and co-workers at Sojo University have published in the Journal of Natural Products on the isolation of a compound that may help prevent atherosclerosis by inhibiting acyl-CoA:cholesterol acyl transferase (ACAT) or “CE” accumulation (cholesterol ester accumulation) at high doses (~50 micromolar – 40% CE accumulation inhibition).  Although the compound, esculeogenin A, was not as effective as the synthetic compound CI976, which inhibited CE accumulation by 90% at 5 micromolar, it was important to point out that the compound is from a natural food source.

esculeoside

JNP paper

Posted in Steroids, Triterpenoids | Leave a Comment »

Anti-Malarial Neemfruitins

Posted by naturalproductman on August 10, 2010

Orazio Taglialatela-Scafali and co-workers from Universita di Napoli “Federico II” in Italy have published in the Journal of Natural Products on the isolation of two triterpenoids dubbed neemfruitins A and B that had antiplasmodial activities of 1.74 and 9.98 micromolar IC50 values against the W2 strain of Plasmodium falciporum.

neemfruitins

JNP paper

Posted in Diseases, Malaria, Steroids, Triterpenoids | Leave a Comment »

Abiesatrine A

Posted by naturalproductman on April 8, 2010

Wei-Dong Zhang and co-workers from the Second Military Medical University have recently reported on the isolation of abiestatrines.  Abiesatrine A possessed anti-tumor activities against QGY-773 cells with an IC50 of 7.3 micrograms/mL.

abiestatrines

OBC paper

Posted in Steroids, Triterpenoids | Leave a Comment »

Shinalactone A

Posted by naturalproductman on February 24, 2010

Han-Dong Sun and co-workers at the Chinese Academy of Sciences have recently published in Organic Letters on a new cytotoxic triterpenoid called shinalactone A.  It had 5.9 micromolar IC50 value against PANC-1 human cancer cell line.

shinalactone
OL paper

Posted in Seven-Membered Rings, Triterpenoids | Leave a Comment »

 
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