Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Unnatural Products’ Category

On tramadol

Posted by naturalproductman on October 4, 2014

Michael Spiteller and co-workers at TU Dortmund have reported in ACIE that tramadol is actually not a natural product. This study just points out the importance of uncovering the biosynthesis pathways of natural products.

tramadol

 

ACIE paper

 

Old post on tramadol

Posted in Unnatural Products | Leave a Comment »

Cholesterol analog to probe SHH protein

Posted by naturalproductman on August 20, 2014

Edward Tate and co-workers from Imperial College in London have reported in Chemical Science on a cholesterol analog that allowed them to probe the sonic hedgehog protein, a peptide that undergoes post-translational modification with cholesterol.

cholesterol

Chemical Science paper

Posted in Chemical Biology, Unnatural Products | Leave a Comment »

Anti-malarial pyrrolopyrazines

Posted by naturalproductman on June 7, 2014

Gisbert Schneider and co-workers from ETH Zurich have reported in ACIE on some anti-malarial pyrrolopyrazines.

ACIE paper

Posted in Diseases, Malaria, Unnatural Products | Leave a Comment »

Fluorinated compounds, biosynthetically

Posted by naturalproductman on September 5, 2013

Michelle Chang and co-workers at Berkeley have reported in Science on a way to access fluorinated natural products using fluoroacetate as the building block.

 

Science paper

Posted in Biosynthesis, Unnatural Products | Leave a Comment »

Tubulexin chemical biology

Posted by naturalproductman on October 25, 2012

Herbert Waldmann and co-workers at Max Planck have reported in ACIE on the chemical biology of tubulexins.

tubulexins

ACIE paper

Posted in Cancer, Chemical Biology, Methodology, Protein Targets, Unnatural Products | Leave a Comment »

Gambierol analogs

Posted by naturalproductman on April 18, 2012

Luis Botana and co-workers from Universidad de Santiago de Compostela, Lugo, Spain have reported in JACS on the synthesis of gambierol analogs.

gambierol

JACS paper

Posted in Methodology, Polyether, Unnatural Products | Leave a Comment »

Vinblastine analogs

Posted by naturalproductman on February 29, 2012

Dale Boger and colleagues have reported in Organic Letters on the functionalization of alkenes using iron. When I first saw vinblastine I thought of Dale Boger because he does so much work on this compound and it looks like I was thinking the right person.

vinblastine

OL paper

Posted in Alkaloids, Iron, Methodology, Transition Metal, Unnatural Products | Leave a Comment »

Vancomycin analogs

Posted by naturalproductman on January 6, 2012

Whenever I see vancomycin’s structure I always think of Dale Boger. This time he and co-workers have published in JACS on the synthesis of some vancomycin analogs.
vancomycin

JACS paper

Posted in Methodology, Peptides, Total Synthesis, Unnatural Products | Leave a Comment »

Fluorinated calystegnine B2

Posted by naturalproductman on December 30, 2011

Jonathan Percy and co-workers at the University of Strathclyde in the UK have reported in JOC on the synthesis of a fluorinated calystegnine B2 analog.

fluorine

JOC paper

Posted in Alkaloids, Computational, DFT, Mechanistic, Methodology, Unnatural Products | Leave a Comment »

Chemical synthesis with biosynthesis

Posted by naturalproductman on December 2, 2011

Andreas Kirschning and co-workers at have reported in ACIEE on a combined biosynthesis/chemical synthesis approach to synthesize new ansamitocin analogs.

combination

ACIEE paper

Posted in Asymmetric, Biosynthesis, Cancer, Cascade Reactions, Methodology, Polyketides, Unnatural Products | Leave a Comment »

 
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