Naturalproductman’s Blog

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Archive for the ‘Unnatural Products’ Category

Cholesterol analog to probe SHH protein

Posted by naturalproductman on August 20, 2014

Edward Tate and co-workers from Imperial College in London have reported in Chemical Science on a cholesterol analog that allowed them to probe the sonic hedgehog protein, a peptide that undergoes post-translational modification with cholesterol.

cholesterol

Chemical Science paper

Posted in Chemical Biology, Unnatural Products | Leave a Comment »

Anti-malarial pyrrolopyrazines

Posted by naturalproductman on June 7, 2014

Gisbert Schneider and co-workers from ETH Zurich have reported in ACIE on some anti-malarial pyrrolopyrazines.

ACIE paper

Posted in Diseases, Malaria, Unnatural Products | Leave a Comment »

Fluorinated compounds, biosynthetically

Posted by naturalproductman on September 5, 2013

Michelle Chang and co-workers at Berkeley have reported in Science on a way to access fluorinated natural products using fluoroacetate as the building block.

 

Science paper

Posted in Biosynthesis, Unnatural Products | Leave a Comment »

Tubulexin chemical biology

Posted by naturalproductman on October 25, 2012

Herbert Waldmann and co-workers at Max Planck have reported in ACIE on the chemical biology of tubulexins.

tubulexins

ACIE paper

Posted in Cancer, Chemical Biology, Methodology, Protein Targets, Unnatural Products | Leave a Comment »

Gambierol analogs

Posted by naturalproductman on April 18, 2012

Luis Botana and co-workers from Universidad de Santiago de Compostela, Lugo, Spain have reported in JACS on the synthesis of gambierol analogs.

gambierol

JACS paper

Posted in Methodology, Polyether, Unnatural Products | Leave a Comment »

Vinblastine analogs

Posted by naturalproductman on February 29, 2012

Dale Boger and colleagues have reported in Organic Letters on the functionalization of alkenes using iron. When I first saw vinblastine I thought of Dale Boger because he does so much work on this compound and it looks like I was thinking the right person.

vinblastine

OL paper

Posted in Alkaloids, Iron, Methodology, Transition Metal, Unnatural Products | Leave a Comment »

Vancomycin analogs

Posted by naturalproductman on January 6, 2012

Whenever I see vancomycin’s structure I always think of Dale Boger. This time he and co-workers have published in JACS on the synthesis of some vancomycin analogs.
vancomycin

JACS paper

Posted in Methodology, Peptides, Total Synthesis, Unnatural Products | Leave a Comment »

Fluorinated calystegnine B2

Posted by naturalproductman on December 30, 2011

Jonathan Percy and co-workers at the University of Strathclyde in the UK have reported in JOC on the synthesis of a fluorinated calystegnine B2 analog.

fluorine

JOC paper

Posted in Alkaloids, Computational, DFT, Mechanistic, Methodology, Unnatural Products | Leave a Comment »

Chemical synthesis with biosynthesis

Posted by naturalproductman on December 2, 2011

Andreas Kirschning and co-workers at have reported in ACIEE on a combined biosynthesis/chemical synthesis approach to synthesize new ansamitocin analogs.

combination

ACIEE paper

Posted in Asymmetric, Biosynthesis, Cancer, Cascade Reactions, Methodology, Polyketides, Unnatural Products | Leave a Comment »

Cribrostatin analogs

Posted by naturalproductman on November 17, 2011

Stephen Martin and colleague have reported in Tetrahedron on their cribrostatin analog synthesis via radical cyclization cascade to access the aromatic ring.  We’ve seen this chemistry before when they reported their synthesis in ACIEE.

analog

Tetrahedron paper

Posted in Alkaloids, Cascade Reactions, Methodology, Radical Chemistry, Unnatural Products | Leave a Comment »

 
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