Edward Tate and co-workers from Imperial College in London have reported in Chemical Science on a cholesterol analog that allowed them to probe the sonic hedgehog protein, a peptide that undergoes post-translational modification with cholesterol.
Archive for the ‘Unnatural Products’ Category
Posted by naturalproductman on August 20, 2014
Posted by naturalproductman on June 7, 2014
Gisbert Schneider and co-workers from ETH Zurich have reported in ACIE on some anti-malarial pyrrolopyrazines.
Posted by naturalproductman on September 5, 2013
Michelle Chang and co-workers at Berkeley have reported in Science on a way to access fluorinated natural products using fluoroacetate as the building block.
Posted by naturalproductman on October 25, 2012
Herbert Waldmann and co-workers at Max Planck have reported in ACIE on the chemical biology of tubulexins.
Posted by naturalproductman on April 18, 2012
Luis Botana and co-workers from Universidad de Santiago de Compostela, Lugo, Spain have reported in JACS on the synthesis of gambierol analogs.
Posted by naturalproductman on January 6, 2012
Whenever I see vancomycin’s structure I always think of Dale Boger. This time he and co-workers have published in JACS on the synthesis of some vancomycin analogs.
Posted by naturalproductman on December 30, 2011
Jonathan Percy and co-workers at the University of Strathclyde in the UK have reported in JOC on the synthesis of a fluorinated calystegnine B2 analog.
Posted by naturalproductman on December 2, 2011
Andreas Kirschning and co-workers at have reported in ACIEE on a combined biosynthesis/chemical synthesis approach to synthesize new ansamitocin analogs.
Posted by naturalproductman on November 17, 2011
Stephen Martin and colleague have reported in Tetrahedron on their cribrostatin analog synthesis via radical cyclization cascade to access the aromatic ring. We’ve seen this chemistry before when they reported their synthesis in ACIEE.