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Archive for the ‘Xanthones’ Category

Mangostin Xanthones

Posted by naturalproductman on March 25, 2011

Douglas Kinghorn and co-workers at Ohio State University have reported in the Journal of Natural Products on the isolation of bioactive xanthones.

xanthone

 

JNP paper

Posted in Xanthones | Leave a Comment »

Configuration of Gambogic Acid

Posted by naturalproductman on November 11, 2010

Douglas Kinghorn and co-workers from Ohio State University have published in the Journal of Natural Products on the structure of gambogic acid as it is related to morellic acid.  They compared the CD spectra of morellic acid and gambogic acid to determine the relative configurations.

gambogic acid

 

JNP paper

Posted in Xanthones | Leave a Comment »

A Mistaken Report

Posted by naturalproductman on March 30, 2010

John van Klink and co-workers at the University of Otago and the University of Calgary have recently reported in Helvetica Chimica Acta on a correction to a reported method for synthesizing xanthones.

xanthone mistake


HCA paper

Posted in Cascade Reactions, Methodology, Ring forming, Xanthones | Leave a Comment »

Non-Regioselective Formation of Xanthones

Posted by naturalproductman on October 20, 2009

Zhihong Peng and co-workers at Hunan University have recently published in Chemical Communications on the synthesis of xanthone rings starting from a salicylaldehyde and 1,2-dibromobenzene.  They used a palladium bischlorobistriphenyl phosphine catalyst to couple the two fragments.  When they used unsymmetrical 1,2-dibromoarene compounds, they have a 1:1 mixture of regioisomers.

xanthone

Chemical Communications paper

Posted in Aromatic, Cascade Reactions, Methodology, Ring forming, Transition Metal, Xanthones | Leave a Comment »

Rugulosone

Posted by naturalproductman on July 24, 2009

At IC50 values of 1 to 2 micrograms/mL activity towards Plasmodium falciparum, some interesting new xanthone containing natural products were isolated by Somdej Kanokmedhakul and co-workers at Khon Kaen University in Thailand.  These natural products were isolated from the fungus Emericella rugulosa.
xanthones

JNP paper

Posted in Aromatic, Xanthones | 1 Comment »

 
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