Naturalproductman’s Blog

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Cavicularin synthesis

Posted by naturalproductman on August 18, 2014

Christopher Beaudry and colleague at Oregon State have reported in ACIE on the synthesis of cavicularin through a Diels-Alder with a vinyl sulfone dienophile.

Diels Alder

ACIE paper

Posted in Aromatic, Diels-Alder, Methodology, Total Synthesis | Leave a Comment »

Mannopeptimycin aglycone synthesis

Posted by naturalproductman on August 18, 2014

Takayuki Doi and co-workers at Tohoku University have reported in JACS on the synthesis of mannopeptimycin aglycone.

mannopeptimycin aglycone

JACS paper

Posted in Aldol, Methodology, Peptides | Leave a Comment »

Viridicatumtoxin B synthesis

Posted by naturalproductman on August 18, 2014

Nicolaou and co-workers have reported in JACS on the synthesis of viridicatumtoxin B.

polyketide

JACS paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Chembiodraw 14.0 Downloading Problems on the Mac?

Posted by naturalproductman on August 9, 2014

Did anybody else have trouble downloading Chembiodraw 14.0 on their macs?

 

My Chembiodraw 13.0 site license expired so I tried to download the new version 14.0 on my mac, but ran into several problems. Every time I would contact the customer support by email or through their website, it would take a long time for a response. The best thing was to get them on the phone.

 

First you need to make sure you have version 10.9 operating system.

 

Even after getting version 10.9, I had trouble with installation of the program because there is some glitch when you download.  I was lucky enough to get a hold of someone when I called their Waltham Massachusetts phone number at 5:30 AM.

On Finder you have to go to the Users folder, then Shared folder, then Library folder, then Preferences folder.

 

Then under Get Info option after right clicking the preferences folder, you have to go to Sharing & Permission in the pop up window. Then you have to let everyone have Read & Write permission.

 

Seems like I am not the only one with this problem because it is under the FAQ section of cambridgesoft.

 

Hope this helps anyone with the time and headache I had.

 

 

 

Posted in Random | Leave a Comment »

Peganumine A

Posted by naturalproductman on July 27, 2014

Hui-Ming Hua and co-workers from Shenyang Pharmaceutical University have reported in Organic Letters on the isolation of peganumine A, which had an IC50 value of 5.8 μM against HL-60 cells.

peganumine A

OL paper

Posted in Alkaloids, Cancer | Leave a Comment »

Rearrange to more complexity

Posted by naturalproductman on July 27, 2014

Paul Hergenrother and co-workers from UIUC have reported in ACIE on an interesting rearrangement to form fenestrane ring systems.

cyclopropane

ACIE paper

Posted in Antibiotics, Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Electrocyclic ring opening to ketonitrones

Posted by naturalproductman on July 27, 2014

Masahiro Terada and co-workers from Tohoku University have reported in Organic Letters on a copper-catalyzed rearrangement to form alpha,beta-unsaturated ketonitrones.

nitrone

OL paper

Posted in Cascade Reactions, Copper, Electrocyclization, Mechanistic, Methodology, Pericyclic reactions, Transition Metal | Leave a Comment »

Aryl halide couplings with Sp3-carbons

Posted by naturalproductman on July 27, 2014

Gary Molander and colleagues reported in Science on a photoredox nickel dual catalysis for a cross coupling reaction between an sp3-hybridized organoboron and an aryl halide.

Science paper (Molander)

In the same issue, David Macmillan and co-workers have reported on a photoredox reaction involving a nickel catalyzed coupling between an sp3-alpha-carboxyl and an aryl halide.

Science paper (Macmillan)

 

Posted in Cascade Reactions, cross coupling, Light Mediated, Methodology, Nickel, Transition Metal | Leave a Comment »

C-O bond cleavage with Ir

Posted by naturalproductman on July 27, 2014

Alan Goldman and co-workers from Rutgers have reported in ACIE on an iridium pincer complex catalyzed C-O bond cleavage.

C-O

ACIE paper

Posted in Catalytic, Iridium, Methodology, Transition Metal | Leave a Comment »

Bislactone desymmetrization

Posted by naturalproductman on July 27, 2014

Jieping Zhu and co-workers have reported in ACIE on the synthesis of rhazinilam and leucomidine B.

desymmetrize

ACIE paper

Posted in Alkaloids, Asymmetric, C2-Symmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

 
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