Naturalproductman’s Blog

Hey, is that a natural product?!

Furan to cyclopentenone from singlet oxygen

Posted by naturalproductman on November 10, 2014

Georgios Vassilikogiannakis from the University of Crete have reported in ACIE on the synthesis of cyclopentenones from furans through an endoperoxide intermediate.
furan

ACIE paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

Advice from Michael Doyle

Posted by naturalproductman on November 10, 2014

Michael Doyle gives advice about writing manuscripts in his ACIE profile article…basically he says to focus on the main points in the manuscript and all of the other details go to the supporting information. The intro persuades the reader to keep on reading. He started off his career as a professor at undergrad only institutions and moved to PhD ones and commented that at the undergrad only institutions, the resources are not as good but the students are top notch.

 

ACIE article

Posted in Random | Leave a Comment »

Tetrodotoxin analogs from a newt

Posted by naturalproductman on November 8, 2014

Mari Yotsu-Yamashita and co-workers at Tohoku University have reported in ACIE on the isolation of some tetrodotoxin analogs from a newt.

tetrodotoxin

ACIE paper

Posted in Alkaloids | Leave a Comment »

Exo vs. endo

Posted by naturalproductman on November 8, 2014

Nicolai Cramer and colleague at EPFL in Switzerland have reported in ACIE on a Ni catalyzed cyclization that undergoes endo or exo cyclization depending on the use of either a carbene or a cyclooctadiene ligand.

cyclo octadiene

ACIE paper

Posted in Methodology, Nickel, Transition Metal | Leave a Comment »

Ascospiroketal A synthesis

Posted by naturalproductman on November 8, 2014

Robert Britton and co-workers from Simon Fraser University have reported in ACIE on the synthesis of ascospiroketal A through a silver cascade reaction.

silver

ACIE paper

Posted in Cascade Reactions, Methodology, Silver, Total Synthesis, Transition Metal | Leave a Comment »

Neopeltolide through metathesis

Posted by naturalproductman on November 8, 2014

Hoveyda and co-workers have reported in ACIE on the synthesis of neopeltolide.

metathesis

ACIE paper

Posted in Metathesis, Methodology, Ruthenium, Total Synthesis, Transition Metal | Leave a Comment »

Depolymerization of lignins

Posted by naturalproductman on November 8, 2014

Nicholas Westwood and co-workers from the University of St. Andrews have reported in ACIE on the breakdown of lignins to form substituted benzenes using a DDQ/tBuONO/O2 system.
depolymerization

ACIE paper

Posted in Methodology, Radical Chemistry | Leave a Comment »

Dibefurin synthesis

Posted by naturalproductman on November 8, 2014

Dirk Trauner and co-workers have reported in ACIE on the synthesis of dibefurin.

dibefurin

ACIE paper

Posted in Protein Targets, Total Synthesis | Leave a Comment »

Alkyl halides from aryl halides

Posted by naturalproductman on November 8, 2014

Zhenfeng Xi and co-workers from SIOC have reported in ACIE on the transfer of a halogen from an aryl group to an alkyl group.

reductive elimination

ACIE paper

Posted in Mechanistic, Methodology, Palladium, Transition Metal | Leave a Comment »

Pd pi-allyl

Posted by naturalproductman on November 8, 2014

Shu-Li You and co-workers at SIOC have reported in JACS on some mechanistic studies of a Pd pi-allyl chemistry.

pi allyl

JACS paper

Posted in Asymmetric, Mechanistic, Methodology, Named Reactions, Palladium, Transition Metal, Tsuji-Trost | Leave a Comment »

 
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