Naturalproductman’s Blog

Hey, is that a natural product?!

From carbenoids to allenoates

Posted by naturalproductman on July 1, 2015

Xiaoming Feng and co-workers from Sichuan University have reported in the transformation of terminal alkynes to allenoates using diazo acetates.

diazo

ACIE paper

Posted in Carbene, Methodology, Organocatalytic | Leave a Comment »

Binaphthylamine catalyzed Michael addition

Posted by naturalproductman on July 1, 2015

When I saw that binaphthylamine on the abstract, I immediately thought of Keiji Maruoka and it was his work.

arylamine

ACIE paper

Posted in Methodology, Michael, Named Reactions, Organocatalytic | Leave a Comment »

From Terminal Diols to Secondary Alcohols

Posted by naturalproductman on July 1, 2015

Bill Morandi and colleague at Max-Planck-Institut für Kohlenforschung have reported in ACIE on a deoxygenation strategy of terminal 1,2-diols to secondary alcohols.

secondary alcohol
ACIE paper

Posted in C-X Bond Breaking, Methodology | Leave a Comment »

Towards naphthocyclinones

Posted by naturalproductman on July 1, 2015

Keisuke Suzuki and co-workers at the Tokyo Institute of Technology have reported in ACIE on their strategy towards Naphthocyclinones.

polyketide

ACIE paper

Posted in Antibiotics, Dimer, Polyketides | Leave a Comment »

Amathaspiramides syntheses

Posted by naturalproductman on July 1, 2015

Daesung Lee and co-workers have reported in ACIE on the syntheses of amathaspiramides.

rearrangement

ACIE paper

Posted in Uncategorized | Tagged: , | Leave a Comment »

Looks like cannabinoids

Posted by naturalproductman on July 1, 2015

Armido Studer and colleague at Westfälische Wilhelms-Universität Münster have reported in ACIE on the syntheses of machaeriols B and D.

total synthesis

ACIE paper

Posted in Uncategorized | Tagged: | Leave a Comment »

Dragmacidin D synthesis

Posted by naturalproductman on July 1, 2015

I first was introduced to dragmacidins when I started reading work about Stoltz’s group, which was published in JACS, but I didn’t know that Zakarian’s group has also been working on its synthesis and published it in ACIE.

dragmacidin

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Alkoxycarbonylation of allenes – regioselective switching by ligand

Posted by naturalproductman on June 30, 2015

Matthias Beller and co-workers have reported in JACS on a ligand controlled regioselectivitiy switching of an alkoxycarbonylation of an allene substrate.

JACS paper

Posted in Methodology, Palladium, Regioselective, Transition Metal | Leave a Comment »

Trichodermamides A, B, and C syntheses

Posted by naturalproductman on June 30, 2015

Oleg Larionov and co-workers at UT San Antonio have reported in JACS on the syntheses of trichodermamides A, B, and C.

polyketide

JACS paper

Posted in Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

α-Ketol rearrangement

Posted by naturalproductman on June 9, 2015

Ulrich Koert and co-workers from Philipps-University Marburg have reported in Organic Letters on an alpha-ketol rearrangment.They heat the reaction in a sealed tube to 70 degrees and the solvent is in DCM – with 2.5 mol equivalents of BF3 etherate, sounds a bit harsh – but nonetheless an interesting sigmatropic rearrangement.

 
ketol
OL paper

Posted in Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

 
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