Naturalproductman’s Blog

Hey, is that a natural product?!

Mechanistic insights towards endoperoxide formation of artemisinin

Posted by naturalproductman on June 17, 2021

Artemisinin, one of the topics of the Nobel Prizes in Medicine in 2015, and its derivatives have been used to treat malaria. A new study published in the Journal of Natural Products finds that the endoperoxide formation of artemisinin from dihydroartemisinic acid, its biosynthetic precursor, undergoes a mixed mechanism. The study, from the lab of Francis Yoshimoto at UTSA, used regioselectively deuterated dihydroartemisinic acid isotopologues to measure competitive intermolecular kinetic isotope effects in the formation of artemisinin. The supporting information file is over 500 pages!

Cool!


Journal of Natural Products
paper

Posted in Antimalarial, Cyclic Peroxides, Diseases, Isotope effects, Malaria, Mass Spectrometry, Mechanistic, Peroxides, Terpenes | Leave a Comment »

Update – SARS CoV-2 Mutants

Posted by naturalproductman on May 22, 2021

Here’s an update related to SARS CoV-2 mutants that are more infective than the original strain. The basis behind more infective strains of SARS CoV-2 seems to be the spike protein, which is the protein the virus uses to enter the human cells.

The Protein Journal

Posted in Uncategorized | Leave a Comment »

SARS CoV-2 update

Posted by naturalproductman on February 26, 2021

Here’s an update on a biochemical perspective of SARS CoV-2 proteins (especially the spike protein).

The Protein Journal

Posted in Anti-viral | Leave a Comment »

Tryptophan labeling

Posted by naturalproductman on September 6, 2020

Michael Taylor and co-workers from the University of Wyoming reported in JACS on a method to label tryptophan residues using an N-carbamoyl pyridinium salt and light.

JACS paper

Posted in Light Mediated, Methodology, Proteins | Leave a Comment »

Zephycarinatines syntheses

Posted by naturalproductman on August 17, 2020

Hiroaki Ohno and co-workers at Kyoto University have reported in ACIE on the synthesis of zephycarinatines.

 

ACIE paper

Posted in Alkaloids, Light Mediated, Total Synthesis | Leave a Comment »

(−)‐Conidiogenone B, (−)‐Conidiogenone, and (−)‐Conidiogenol syntheses

Posted by naturalproductman on August 17, 2020

Hongbin Zhai and co-workers from Peking University have reported in ACIE on the synthesis of conidiogenone B, conidiogenone and conidiogenol.

 

ACIE paper

Posted in Diterpene, Total Synthesis | Leave a Comment »

Disciformycin B synthesis

Posted by naturalproductman on August 17, 2020

Karl-Heinz Altmann and co-worker from ETH Zurich have reported in ACIE on the synthesis of disciformycin B.

 

ACIE paper

Posted in Antibiotics, Total Synthesis | Leave a Comment »

(−)‐Akuammicine and (−)‐strychnine syntheses

Posted by naturalproductman on August 17, 2020

Thomas Snaddon and co-workers from Indiana University have reported in ACIE on the synthesis of (−)‐akuammicine and (−)‐strychnine.

 

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Cornexistin synthesis

Posted by naturalproductman on August 17, 2020

Thomas Magauer and co-workers from Universität Innsbruck in Austria have reported in ACIE on the synthesis of

 

ACIE paper

Posted in Nozaki-Hiyama-Kishi, Total Synthesis | Leave a Comment »

Dippinine B and C synthesis

Posted by naturalproductman on August 17, 2020

Fu-She Han and co-workers from the Chinese Academy of Sciences have reported in ACIE on the synthesis of dippinine B and C.

 

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »