Naturalproductman’s Blog

Hey, is that a natural product?!

Englerin A inhibits TRPC4 and TRPC5

Posted by naturalproductman on February 23, 2015

Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A.
englerin A

ACIE paper

Posted in Chemical Biology, Protein Targets, Sesquiterpenes | Leave a Comment »

Paving the way for a new generation of academic scientists

Posted by naturalproductman on February 23, 2015

I thought this was an interesting article from C&E News regarding faculty retiring. It has comments from Albert Padwa and Edwin Vedejs, some powerhouses in organic chemistry research.

I know it must be a bitter feeling to have to stop doing research for ~50 years of your life, but I do agree that the younger generation needs to be accommodated in terms of funding and research space, because if an academic stays in his lab space for so long preventing a new generation to enter the university, then wouldn’t there be a gap for the next generation of scientists? It used to be normal for PhD scientists to start their labs at age 27, but now it’s becoming more common for people to have 8 year postdocs even or doing multiple postdocs (I guess this is more for biology too) and they will start their academic position at mid to late 30s. I wonder how the universities hiring new “young” faculty feel about hiring someone so old?

C&E News article

Posted in Random | Leave a Comment »

Modern day advances in the industry

Posted by naturalproductman on February 22, 2015

Jacketed reactor vessels, automated parallel reactor systems, flow chemistry, high-throughput parallel screening platforms, are all new types of reaction set ups advanced from our classical round bottom flask equipped with stir bars that industry chemists are using nowadays.  Check out this neat perspective in JOC by Stéphane Caron and Nicholas Thomson at Pfizer.

JOC paper

Posted in New Setups | Leave a Comment »

Antroquinonol synthesis

Posted by naturalproductman on February 22, 2015

Chinpiao Chen and co-worker from National Dong Hwa University have reported in Organic Letters on the syntheses of antroquinononol and antroquinonol D.

antroquinonol

OL paper

Posted in Iridium, Sesquiterpenes, Total Synthesis, Transition Metal | Leave a Comment »

Coprisamides A and B

Posted by naturalproductman on February 22, 2015

Dong-Chan Oh and co-workers from Seoul National University have reported in Organic Letters on the isolation of coprisamides A and B from gut bacteria of beetles.

coprisamides

OL paper

Posted in Peptides | Leave a Comment »

Resveratrol dimer synthesis

Posted by naturalproductman on February 22, 2015

Corey Stephenson at the University of Michigan have reported in ACIE on the synthesis of resveratrol dimers.

dimers

ACIE paper

Posted in Dimer, Total Synthesis | Leave a Comment »

Brefeldin A synthesis

Posted by naturalproductman on February 22, 2015

Alois Furstner and colleague have reported in ACIE on the synthesis of brefeldin A.

brefeldin A

ACIE paper

Posted in Macrocycles, Total Synthesis | Leave a Comment »

Tetracycline analogs

Posted by naturalproductman on February 22, 2015

Hrvoje Petkovic and co-workers at University of Ljubljana have reported in ACIE on a biosynthetic engineering approach to produce new tetracycline compounds.

tetracycline

ACIE paper

Posted in Biosynthesis, Chemical Biology, Polyketides, Tetracycline | Leave a Comment »

Circular dichroism approach to determine chirality

Posted by naturalproductman on February 22, 2015

Babak Borhan and co-workers have reported in ACIE on a way to determine remote chirality using the cotton effect and molecular tweezers.

molecular tweezers

ACIE paper

Posted in Methodology, Molecular tweezers, New Setups, Stereochemistry | Leave a Comment »

Miuraenamide sythesis

Posted by naturalproductman on February 22, 2015

Uli Kazmeier and co-workers at Saarland University have reported in ACIE on the synthesis of miuraenamides.

miuraenamides

ACIE paper

Posted in Macrocycles, Total Synthesis | Leave a Comment »

 
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