Naturalproductman’s Blog

Hey, is that a natural product?!

Eupalinilide E synthesis

Posted by naturalproductman on May 4, 2016

Dionicio Siegel and co-workers reported in JACS on the synthesis of eupalinilide E, which promotes hematopoietic stem and progenitor cells (HSPCs) expansion.

 

JACS paper

Posted in Stem Cells, Total Synthesis | Leave a Comment »

Gonyautoxin 2, gonyautoxin 3, and 11,11-dihydroxysaxitoxin syntheses

Posted by naturalproductman on May 4, 2016

Justin Du Bois and co-workers reported in JACS on the syntheses of gonyautoxin 2, gonyautoxin 3, and 11,11-dihydroxysaxitoxin.

 

JACS paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Rubriflordilactone B synthesis

Posted by naturalproductman on May 3, 2016

Ang Li and co-workers reported in ACIE on the synthesis of rubriflordilactone B.

 

ACIE paper

Posted in Lactones, Total Synthesis | Leave a Comment »

Iron-catalyzed cross coupling between Grignard reagents and enol carbamates

Posted by naturalproductman on May 3, 2016

Doug Frantz and co-workers from UTSA have reported in ACIE on an iron-catalyzed cross-coupling reaction between enol carbamates and Grignard reagents.

 

ACIE paper

Posted in cross coupling, Iron, Methodology, Transition Metal | Leave a Comment »

Palau’amine synthesis

Posted by naturalproductman on April 28, 2016

Here’s another total synthesis of palau’amine by Keiji Tanino and co-workers from Hokkaido University. I can’t believe I missed it.

 

Nature Communications paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

(−)-Terengganensine A synthesis

Posted by naturalproductman on April 20, 2016

Jieping Zhu and co-workers have reported in ACIE on the synthesis of (−)-terengganensine A.

 

ACIE paper

Posted in Alkaloids, Indoles, Total Synthesis | Leave a Comment »

Propargylic benzoate to allene

Posted by naturalproductman on April 19, 2016

Erick Carreira and colleague have reported in Organic Letters on a rhodium catalyzed synthesis of chiral allenes from propargylic benzoates.

 

OL paper

Posted in Allenes, Methodology, Rhodium, Transition Metal | Leave a Comment »

Markovnikov addition – terminal alkynes to ketones

Posted by naturalproductman on April 19, 2016

Chao-Jun Li and co-workers from McGill University reported in Organic Letters on a useful transformation that converts a terminal alkyne to a ketone using trifluoroethanol as the solvent and triflic acid.

 

OL paper

Posted in Alkynes, Cascade Reactions, Methodology | Leave a Comment »

From a dithiane-vinyl chloride to furan

Posted by naturalproductman on April 19, 2016

Shouchu Tang and co-workers from Lanzhou University have reported in Organic Letters on an interesting transformation that undergoes an allene intermediate.

 

OL paper

Posted in Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Desymmetrization with proline and Pd

Posted by naturalproductman on April 19, 2016

Yi-Xia Jia and co-workers from Zhejiang University have reported in JACS on an intramolecular desymmetrization by a Heck reaction.

 

JACS paper

Posted in Desymmetrization, Heck, Methodology, Mizoroki-Heck, Organocatalytic, Palladium, Transition Metal | Leave a Comment »

 
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