Naturalproductman’s Blog

Hey, is that a natural product?!

Hypocrolide A synthesis

Posted by naturalproductman on September 13, 2016

Chuang-Chuang Li and co-workers from South China University of Science and Technology of China have reported in Organic Letters on the synthesis of hypocrolide A.

 

OL paper

Posted in Total Synthesis | Leave a Comment »

Article view metrics

Posted by naturalproductman on September 13, 2016

I noticed a new statistic on JACS papers. It has an “Article View Metrics” feature on the right hand side when you click on the abstract of any JACS article.

What is interesting is to notice the popularity of the type of chemistry based on the field: e.g. total synthesis, reaction methodology, enzyme mechanism, mass spectrometry techniques, etc.

My observation is that the synthetic organic chemistry field seems to be popular with more article views on that research area. I wonder if it’s because the regular JACS audience comprise more people from that research focus.

Posted in Random | Leave a Comment »

Reversing the epoxidation

Posted by naturalproductman on September 7, 2016

Rongbiao Tong and co-workers from the Hong Kong University of Science and Technology reported in Organic Letters on a copper catalyzed de-epoxidation reaction.

OL paper

Posted in Copper, Methodology | Leave a Comment »

C-H Allylation

Posted by naturalproductman on September 7, 2016

Hon-Wai Lam and co-workers from the University of Nottingham have reported in JACS on a rhodium catalyzed C-H allylation process.

 

JACS paper

Posted in C-H activation, Rhodium | Leave a Comment »

Regarding Reproducibility

Posted by naturalproductman on September 6, 2016

Bob Bergman and Rick Danheiser have published an article on steps to enhance reproducibility in chemical research. One approach is to take a co-worker who has no experience in the new chemical reaction reported, and have them repeat the experiment based on the supporting information alone.

 

ACIE paper

Posted in Random | Leave a Comment »

Gold cascade

Posted by naturalproductman on August 23, 2016

Rai-Hsiung Liu and co-workers from National Tsinghua University have reported in ACIE on a gold-catalyzed conversion of an alkynyl ketone to a cyclopentenone.

 

ACIE paper

Posted in Uncategorized | Leave a Comment »

Cope rearrangement

Posted by naturalproductman on August 23, 2016

James Gleason and colleague at McGill University have reported in ACIE on an organocatalytic Cope rearrangement.

 

ACIE paper

Posted in Cascade Reactions, Methodology, Organocatalytic, Sigmatropic Rearrangements | Leave a Comment »

Harringtonolide

Posted by naturalproductman on August 23, 2016

Hongbin Zhai and co-workers from Peking University have reported in ACIE on the synthesis of harringtonolide through a [3+2] reaction.

 

ACIE paper

Posted in Diterpenoids, Total Synthesis | Leave a Comment »

Prymnesins

Posted by naturalproductman on August 23, 2016

Thomas Ostenfeld Larsen and co-workers at Technical University of Denmark reported in the isolation of B-type prymnesins from microalga. These look like the big brevetoxins.

 

JNP paper

Posted in Polyketides | Leave a Comment »

Carbonylative spirolactonization

Posted by naturalproductman on August 22, 2016

Mingji Dai and co-workers reported in JACS on a Pd-catalyzed spirolactonization.

 

JACS paper

Posted in Cascade Reactions, Methodology, Palladium | Leave a Comment »