Naturalproductman’s Blog

Hey, is that a natural product?!

4pi-Electrocyclic ring opening cascade

Posted by naturalproductman on July 23, 2015

Kiyosei Takasu and co-workers from Kyoto University have reported in JACS on a ring expansion cross coupling cascade.

JACS paper

Posted in Cascade Reactions, Electrocyclization, Methodology, Palladium, Transition Metal | Leave a Comment »

Oridamycin synthesis

Posted by naturalproductman on July 22, 2015

Another solo performance from Danishefsky’s lab published by Adam Trotta.

OL paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

What kind of heterocycles are in drugs?

Posted by naturalproductman on July 22, 2015

This is a good review by Jon Njardarson and co-workers in Journal of Medicinal Chemistry on the analysis of heterocycles in FDA approved drugs.
heterocycles
JMC paper

Posted in Medicinal Chemistry | Leave a Comment »

Penibruguieramine A synthesis

Posted by naturalproductman on July 22, 2015

Sanghee Kim and co-workers from Seoul National University have reported in ACIE on the synthesis of penibruguieramine A.

alkaloid

ACIE paper

Posted in Alkaloids, Asymmetric, Kinetic resolution, Methodology, Total Synthesis | Leave a Comment »

Hosieine A synthesis

Posted by naturalproductman on July 22, 2015

Ran Hong and co-workers at SIOC have reported in ACIE on the synthesis of hosieine A. The pyridone moiety reminds of lyconadin.

alkaloid

ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Englerin A synthesis

Posted by naturalproductman on July 20, 2015

Shunichi Hashimoto and co-workers from Hokkaido University have reported in Chemistry a European Journal on their total synthesis of englerin A.

Chemistry – a European Journal paper

Posted in Sesquiterpenes, Total Synthesis | Leave a Comment »

Iron cross coupling with vinyl acetates

Posted by naturalproductman on July 17, 2015

Axel Jacobi von Wangelin and co-workers at the University of Regensburg have reported in ACIE on an iron catalyzed cross coupling between alkenyl acetates and an alkyl magnesium halide unit.

iron

ACIE paper

Posted in cross coupling, Iron, Transition Metal | Leave a Comment »

Yaku’amide synthesis

Posted by naturalproductman on July 17, 2015

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of yaku’amide.

peptide

JACS paper

Posted in Peptides, Structural Reassignment | Leave a Comment »

Machines in organic synthesis

Posted by naturalproductman on July 17, 2015

Steven Ley and co-workers reported in ACIE on a review of the different machines people use to make small molecules. I like the use of actual photographs of the equipment…

photos

ACIE paper

Posted in Methodology, New Setups, New Types | Leave a Comment »

Nannocystin A

Posted by naturalproductman on July 17, 2015

Dominic Hoepfner and co-workers from Novartis have reported in ACIE on nannocystin A, which had similar binding properties with didemin B on EF-1alpha (elongation factor 1 inhibitor).

nannocystin A

ACIE paper

Mark Brönstrup and co-workers at Helmholtz Zentrum für Infektionsforschung also reported on the isolation of this small molecule. I wonder if there’s a relationship between the two studies.

ACIE paper

the novartis paper states that their study parallels the work in helmholtz. I guess the two studies just coincidentally resulted in the isolation of the same compound.

Posted in Biosynthesis, Cancer, Chemical Biology, Macrocycles, Macrolides, Peptides | Leave a Comment »

 
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