Naturalproductman’s Blog

Hey, is that a natural product?!

Good mentoring

Posted by naturalproductman on May 23, 2016

Here’s a document listing how to be a good mentor/mentee. Things I got out of it: good mentees respect the time of mentors so always come prepared before approaching your mentor.

Mentoring

Posted in Mentoring, Random | Leave a Comment »

Minfiensine synthesis

Posted by naturalproductman on May 17, 2016

Lei Jiao and co-workers from Tsinghua University have reported in ACIE on the synthesis of minfiensine.

 

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Aminoglycoside biosynthesis

Posted by naturalproductman on May 17, 2016

Qi Zhang and co-workers from Fudan University have reported in JACS on a C3-deoxygenation pathway found in apramycin biosynthesis. A radical SAM enzyme is responsible for dehydrating the hydroxy group.

 

JACS paper

Posted in Biosynthesis | Leave a Comment »

Dictyoxetane synthesis

Posted by naturalproductman on May 17, 2016

Thomas Magauer and colleague at LMU have reported in JACS on the synthesis of dictyoxetane.

 

JACS paper

Posted in Sesquiterpenes, Total Synthesis | Leave a Comment »

Mechanism of a Diels-Alderase Enzyme

Posted by naturalproductman on May 7, 2016

Paul Race and co-workers from the University of Bristol have reported in JACS on the details of how an enzyme catalyzes a Diels-Alder reaction using crystal structures and enzyme assays. The enzyme is called spirotetronate cyclase AbyU and is key in forming the macrocyclic structure of abyssomicin C.

 

JACS paper

Posted in Diels-Alder, Enzymes | Leave a Comment »

Eupalinilide E synthesis

Posted by naturalproductman on May 4, 2016

Dionicio Siegel and co-workers reported in JACS on the synthesis of eupalinilide E, which promotes hematopoietic stem and progenitor cells (HSPCs) expansion.

 

JACS paper

Posted in Stem Cells, Total Synthesis | Leave a Comment »

Gonyautoxin 2, gonyautoxin 3, and 11,11-dihydroxysaxitoxin syntheses

Posted by naturalproductman on May 4, 2016

Justin Du Bois and co-workers reported in JACS on the syntheses of gonyautoxin 2, gonyautoxin 3, and 11,11-dihydroxysaxitoxin.

 

JACS paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Rubriflordilactone B synthesis

Posted by naturalproductman on May 3, 2016

Ang Li and co-workers reported in ACIE on the synthesis of rubriflordilactone B.

 

ACIE paper

Posted in Lactones, Total Synthesis | Leave a Comment »

Iron-catalyzed cross coupling between Grignard reagents and enol carbamates

Posted by naturalproductman on May 3, 2016

Doug Frantz and co-workers from UTSA have reported in ACIE on an iron-catalyzed cross-coupling reaction between enol carbamates and Grignard reagents.

 

ACIE paper

Posted in cross coupling, Iron, Methodology, Transition Metal | Leave a Comment »

Palau’amine synthesis

Posted by naturalproductman on April 28, 2016

Here’s another total synthesis of palau’amine by Keiji Tanino and co-workers from Hokkaido University. I can’t believe I missed it.

 

Nature Communications paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

 
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