Naturalproductman’s Blog

Hey, is that a natural product?!

Palladium – olefin/insertion cascade

Posted by naturalproductman on July 4, 2016

Vellaisamy Sridharan and co-workers from SASTRA University have reported in Organic Letters on a palladium catalyzed hydration olefin-insertion cascade.

 

OL paper

Posted in Cascade Reactions, Methodology, Palladium | Leave a Comment »

Siloxydifluorocyclopropanes open

Posted by naturalproductman on July 4, 2016

Mang Wang and co-workers from Northeast Normal University have reported in Organic Letters on a ring opening reaction of siloxy difluorocyclopropane to access difluorocyclopentenones.

 

OL paper

Posted in Ring Opening | Leave a Comment »

Sulfur ylides with copper allenylidenes

Posted by naturalproductman on July 4, 2016

Wen-Jing Xiao and co-workers from Central China Normal University have reported in JACS on an asymmetric [4+1] reaction between a copper allenylidene and sulfur ylide.

 

JACS paper

Posted in Asymmetric, Carbene, Copper, Methodology, Transition Metal | Leave a Comment »

Chiral allenes via Mukaiyama-Aldol

Posted by naturalproductman on July 4, 2016

Benjamin List and co-workers at Max-Planck-Institut für Kohlenforschung reported in ACIE on a Mukaiyama-Aldol approach to access axially chiral allenes.
ACIE paperACIE paperACIE paper

Posted in Allenes, Methodology, Mukaiyama, Named Reactions, Organocatalytic | Leave a Comment »

Calophyline A synthesis

Posted by naturalproductman on July 4, 2016

Liansuo Zu and co-workers from Tsinghua University have reported in ACIE on the synthesis of calophyline A.

 

ACIE paper

Posted in Indolines | Leave a Comment »

Writing in Chemistry – Woodward as an example

Posted by naturalproductman on July 4, 2016

Jeffrey Seeman from the University of Richmond reported in ACIE on the writing style of Woodward. I like what it says in the end of the account: “if only more chemists can relate their work as well, using their own language and style” – meaning don’t try to be a copycat version of Woodward, but instead be as good of a writer in your own way.

 

ACIE paper

Posted in Random | Leave a Comment »

Siloxydiene meets a 1,3-dicarbonyl

Posted by naturalproductman on June 16, 2016

Justin Mohr and co-workers at the University of Illinois in Chicago have reported in Organic Letters on a Mn-promoted oxidative coupling between a siloxydiene and a 1,3-dicarbonyl. They use 2.25 mol equivalents of Mn though so there’s room to make it better?

 

OL paper

Posted in Manganese, Transition Metal | Leave a Comment »

Communensin F synthesis

Posted by naturalproductman on June 16, 2016

Mohammed Movassaghi and co-workers reported in JACS on the synthesis of communensin F.

 

JACS paper

Posted in Alkaloids, Methodology, Radical Chemistry, Total Synthesis | Leave a Comment »

Mechanism of hexadehydro Diels Alder

Posted by naturalproductman on June 16, 2016

Thomas Hoye and co-workers reported in JACS on a substituent effect on the rate of the hexadehydro-Diels Alder reaction. Unlike the regular Diels-Alder reaction, electron-withdrawing groups slowed the reaction down suggesting a step-wise diradical mechanism as opposed to a concerted mechanism.

 

JACS paper

Posted in Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Pallambins C and D syntheses

Posted by naturalproductman on June 13, 2016

Phil Baran and co-workers reported in JACS on the total syntheses of pallambins C and D.

 

JACS paper

Posted in Total Synthesis | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 83 other followers