Naturalproductman’s Blog

Hey, is that a natural product?!

Ranitidine – Heartburn Medicine – Recall

Posted by naturalproductman on September 25, 2019

Here’s something that may be of interest: ranitidine, a heartburn medication, is being recalled for being contaminated with n-nitrosodimethylamine (NDMA), a known carcinogen. Nitrosamines in general alkylate DNA and cause cancer.

 

FDA announcement for ranitidine

 

 

FDA announcement for valsartan

Posted in Cancer, Random | Leave a Comment »

Publishing ethically

Posted by naturalproductman on July 24, 2019

I very much appreciated this editorial from the editor of Analytical Chemistry (Jonathan Sweedler). Take home message is: don’t fragment research reports to multiple papers (don’t “salami” your work).

 

Analytical Chemistry editorial

 

 

ACS ethical guidelines

Posted in Ethics | Leave a Comment »

Synthesis of 7alpha-hydroxy-cholest-4-en-3-one

Posted by naturalproductman on July 11, 2019

Francis Yoshimoto and co-workers at UTSA have reported in Steroids on the synthesis of 7alpha-hydroxycholest-4-en-3one, a biomarker for irritable bowel syndrome and bile acid malabsorption.

Screen Shot 2019-07-11 at 7.55.35 PM

Steroids paper

Posted in Uncategorized | Leave a Comment »

The Synthesis of 12alpha-Hydroxy Steroids

Posted by naturalproductman on November 3, 2018

Francis Yoshimoto and co-workers at the University of Texas at San Antonio reported in Steroids on the synthesis of 12alpha-hydroxy steroid derivatives to biochemically characterize P450 8B1, the enzyme implicated in cardiovascular health and obesity. Both 7-keto DHEA and 12alpha-hydroxy 7-keto DHEA had antagonistic properties towards the NMDA receptor.

Screen Shot 2018-11-03 at 3.27.25 PM

 

Steroids paper

Posted in C-H activation, Stereochemistry, Steroids, Total Synthesis | Leave a Comment »

First paper published

Posted by naturalproductman on November 6, 2017

Francis Yoshimoto and co-workers at the University of Texas at San Antonio report in the journal, Steroids, on the synthesis of a neurosteroid produced in the brains, 7alpha-hydroxypregnenolone, through an allylic C7-oxidation reaction. The oxidation was performed through either a C7-oxidation through CrO3 in the presence of 3,5-dimethylpyrazole followed by a stereoselective reduction or a regioselective and stereoselective allylic benzoyloxylation using CuBr and tert-butylperoxy benzoate.

STEROIDS FKY

Steroids paper

Posted in C-H activation, Stereochemistry, Steroids, Total Synthesis | Leave a Comment »

And the winners are…

Posted by naturalproductman on October 5, 2016

Nobel prize in chemistry 2016 for the design and synthesis of molecular machines.

Posted in Random | Leave a Comment »

Hypocrolide A synthesis

Posted by naturalproductman on September 13, 2016

Chuang-Chuang Li and co-workers from South China University of Science and Technology of China have reported in Organic Letters on the synthesis of hypocrolide A.

 

OL paper

Posted in Total Synthesis | Leave a Comment »

Article view metrics

Posted by naturalproductman on September 13, 2016

I noticed a new statistic on JACS papers. It has an “Article View Metrics” feature on the right hand side when you click on the abstract of any JACS article.

What is interesting is to notice the popularity of the type of chemistry based on the field: e.g. total synthesis, reaction methodology, enzyme mechanism, mass spectrometry techniques, etc.

My observation is that the synthetic organic chemistry field seems to be popular with more article views on that research area. I wonder if it’s because the regular JACS audience comprise more people from that research focus.

Posted in Random | Leave a Comment »

Reversing the epoxidation

Posted by naturalproductman on September 7, 2016

Rongbiao Tong and co-workers from the Hong Kong University of Science and Technology reported in Organic Letters on a copper catalyzed de-epoxidation reaction.

OL paper

Posted in Copper, Methodology | Leave a Comment »

C-H Allylation

Posted by naturalproductman on September 7, 2016

Hon-Wai Lam and co-workers from the University of Nottingham have reported in JACS on a rhodium catalyzed C-H allylation process.

 

JACS paper

Posted in C-H activation, Rhodium | Leave a Comment »