Naturalproductman’s Blog

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A New Tetrahydrofuranyl Synthesis

Posted by naturalproductman on February 26, 2009

Tristan Lambert at Columbia University has come up with yet another clever methodology. Using Bismuth as the catalyst, he starts with an enal and reacts with a nucleophile. The nucleophile attacks the aldehyde and a hydroalkoxylation follows. It’s a very neat and simple looking protocol.

Lambert's hydroalkoxylation reaction

Org. Lett.

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