Naturalproductman’s Blog

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Spirocyclic Centers Via Claisen Rearrangement

Posted by naturalproductman on June 16, 2009

Susumu Kobayashi at the Tokyo University of Science has recently published in SYNLETT on a pretty neat reaction:  a Claisen rearrangement that gives rise to spirocyclic quaternary centers.  The reaction involves heating the substrate in a sealed tube.

spirocycle

SYNLETT paper

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