Naturalproductman’s Blog

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Ambiguine Isonitriles

Posted by naturalproductman on June 24, 2009

A group of ambiguine isonitriles were isolated in the lab of Jimmy Orjala at the University of Illinois in Chicago from the cyanobacterium Fischerella ambigua.  Ambiguine A isonitrile had the most potent activity towards B. anthracis with a MIC of 1.0 micromolar.  These molecules are structurally and biogenetically related to hapalindoles.

ambiguine isonitriles

JNP paper


One Response to “Ambiguine Isonitriles”

  1. Edinburgher said

    You can put your money on Baran making those molecules in a couple of years time

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