Posted by naturalproductman on July 6, 2009
Alejandro Barrero at the University of Granada in Spain and co-workers have recently published in JOC on the synthesis of an anti-inflammatory agent, myrrhanol A. A key step in the synthesis was the reaction they used to make the 6,6-scaffold of the molecule, which involved a cascade titanium mediated bis-olefin epoxide opening cyclization.
This entry was posted on July 6, 2009 at 6:38 am and is filed under Cascade Reactions, cross coupling, Methodology, Polypodanes, Ring forming, Transition Metal, Triterpenes. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.