Naturalproductman’s Blog

Hey, is that a natural product?!

A Novel Rearrangement

Posted by naturalproductman on July 8, 2009

A pretty cool rearrangement involving the opening of an epoxy-homopropargylic alcohol substrate using either tosic acid or aluminum trichloride to yield a beta-allenyl alpha-hydroxy ketone was discovered by Yong-Min Liang and co-workers at Lanzhou University.  This reaction was recently published in Organic Letters.

allene

Org. Lett. paper

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

 
%d bloggers like this: