Naturalproductman’s Blog

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A New Approach To Taxol

Posted by naturalproductman on July 17, 2009

Gerald Pattenden at the University of Nottingham has recently published in Tetrahedron on an intramolecular radical cyclization approach to access the 8,6-ring system of taxol starting from an alkynyl ketone, enone and a terminal iodide functionalities in the starting material.

taxol

Tetrahedron paper

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