Cascade Heck Reaction
Posted by naturalproductman on July 27, 2009
Yimin Hu et al at Anhui Normal University in China have recently published in Chemical Communications on a Heck-cascade reaction that leads to five contiguous stereocenters. It’s not only an intermolecular coupling between an aryl halide and an alpha-beta-unsaturated amide, but also a cyclization that leads to the formation of two new rings – it almost looks like a Diels-Alder reaction except that there is an extra functional group introduced.
This entry was posted on July 27, 2009 at 12:15 pm and is filed under Cascade Reactions, cross coupling, Methodology, Ring forming, Transition Metal. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.