Naturalproductman’s Blog

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Ni Catalyzed Hydroacylation

Posted by naturalproductman on July 28, 2009

Michinori Suginome, Toshimichi Ohmura and co-workers from Kyoto University have recently published in JACS on a hydroacylation reaction catalyzed by Ni(c0d)2 (5 mol%) to potentially yield quaternary centers.  The substrate they reacted the aldehyde with was a vinyl cyclopropane which opened on the saturated end.

ni reaction

JACS paper

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