Naturalproductman’s Blog

Hey, is that a natural product?!

Ni Catalyzed Hydroacylation

Posted by naturalproductman on July 28, 2009

Michinori Suginome, Toshimichi Ohmura and co-workers from Kyoto University have recently published in JACS on a hydroacylation reaction catalyzed by Ni(c0d)2 (5 mol%) to potentially yield quaternary centers.  The substrate they reacted the aldehyde with was a vinyl cyclopropane which opened on the saturated end.

ni reaction

JACS paper

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

 
%d bloggers like this: