Naturalproductman’s Blog

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Ugi Reaction to Make Dihydrophenanthridines

Posted by naturalproductman on July 28, 2009

Last year, Jieping Zhu et al at CNRS published in nthe Beilstein Journal of Organic Chemistry on a four component Ugi reaction followed by an intramolecular C-H functionalization to form a diaryl C-C bond between an aryl halide and an aryl group.  Overall this is a useful method to make dihydrophenanthridines.

dihydrophenanthridines

BJOC paper

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