Naturalproductman’s Blog

Hey, is that a natural product?!

A Five Component Reaction

Posted by naturalproductman on July 29, 2009

Carlos Marcos et al at the Universidad de Extremadura have recently published on a five component coupling reaction in JOC.  Well, basically it’s an Ugi followed by condensation with an amine to form a spiropyrrolidinochromanone.  Ugi reactions normally consist of an aldehyde or ketone, isocyanide, amine and carboxylic acid.  The special type of Ugi reaction we see here has an aldehyde with extra functionality – a chromone moiety.

5 component reaction

JOC paper

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

 
%d bloggers like this: