Naturalproductman’s Blog

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A Five Component Reaction

Posted by naturalproductman on July 29, 2009

Carlos Marcos et al at the Universidad de Extremadura have recently published on a five component coupling reaction in JOC.  Well, basically it’s an Ugi followed by condensation with an amine to form a spiropyrrolidinochromanone.  Ugi reactions normally consist of an aldehyde or ketone, isocyanide, amine and carboxylic acid.  The special type of Ugi reaction we see here has an aldehyde with extra functionality – a chromone moiety.

5 component reaction

JOC paper

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