Naturalproductman’s Blog

Hey, is that a natural product?!

Uncialamycin Progress

Posted by naturalproductman on July 29, 2009

Nicolau has already synthesized uncialamycin.  However, just because one person has completed the synthesis, it doesn’t mean there will be more elegant ways to access the same target molecule.  This enediyne natural product was isolated from a streptomycete isolated from the surface of a lichen, Cladonia uncialis.  It has interesting anti-tumor activities.  The highlight of the synthesis from Pierre van de Weghe from the Universite de Rennes in France is the intramolecular imino-alkyne diels alder to form a subsituted quinoline.  You can check out the synthesis in JOC.

JOC paper

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