Naturalproductman’s Blog

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Four Component Reaction

Posted by naturalproductman on July 30, 2009

Shu-Jiang Tu (Xuzhou Normal University and Suzhou University) and coworkers in collaboration with Guigen Lee (Texas Tech) and co-workers have recently published in JACS on a four component reaction that involves the combining of an aldehyde, ketone and two cyanoamides to form tricyclic 5,6,6-rings that look like alkaloid type molecules. It’s a simple protocol that requires microwave heating at 120 degrees celsius for 12 min in the presence of 1 equivalent of potassium carbonate.

microwave mcc

JACS article


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