Naturalproductman’s Blog

Hey, is that a natural product?!

Four Component Reaction

Posted by naturalproductman on July 30, 2009

Shu-Jiang Tu (Xuzhou Normal University and Suzhou University) and coworkers in collaboration with Guigen Lee (Texas Tech) and co-workers have recently published in JACS on a four component reaction that involves the combining of an aldehyde, ketone and two cyanoamides to form tricyclic 5,6,6-rings that look like alkaloid type molecules. It’s a simple protocol that requires microwave heating at 120 degrees celsius for 12 min in the presence of 1 equivalent of potassium carbonate.

microwave mcc

JACS article

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

 
%d bloggers like this: