Naturalproductman’s Blog

Hey, is that a natural product?!

Platensimycin Studies

Posted by naturalproductman on July 31, 2009

Sheo Singh and co-workers at Merck have recently published in Tetrahedron Letters on the interaction of platensimycin with the enzyme FabF, an enzyme found in the fatty acid biosynthetic pathway.  Inhibition of these classes of enzymes leads to the compound’s antibiotic activity.  They even have a co-crystal structure reported in the paper between the molecule and the enzyme.

platensimycin

Nature paper

TL paper

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