Naturalproductman’s Blog

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Sinulaparvalides A and B

Posted by naturalproductman on August 3, 2009

With IC50 values of 14 micrograms/mL and 10 micrograms/mL against HCT-116 tumor cell lines a diepoxycembrenolide and sinulaflexiolide K were isolated not for the first time by a team led by Yue-Wei Guo from the Chinese Academy of Sciences. They did however isolate two new cembrane diterpenoids, sinulaparvalides A and B, however, they weren’t active compared to the known ones.

sinulaflexiolide

Helvetica Chimica Acta paper

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