Posted by naturalproductman on August 7, 2009
Karl Scheidt and co-workers have recently published a full paper in JACS on their account of the synthesis of neopeltolide, a compound isolated from a sponge and also has nanomolar to subnanomolar IC50 values towards cancer cell lines. The macrocyclic structure that contains a tetrahydropyran ring was formed via a Prins cyclization in one step using scandium triflate.
This entry was posted on August 7, 2009 at 8:07 am and is filed under Cascade Reactions, Macrocycles, Methodology, Tetrahydropyran, Transition Metal. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.