Naturalproductman’s Blog

Hey, is that a natural product?!


Posted by naturalproductman on August 7, 2009

Karl Scheidt and co-workers have recently published a full paper in JACS on their account of the synthesis of neopeltolide, a compound isolated from a sponge and also has nanomolar to subnanomolar IC50 values towards cancer cell lines.  The macrocyclic structure that contains a tetrahydropyran ring was formed via a Prins cyclization in one step using scandium triflate.


JACS paper


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