Naturalproductman’s Blog

Hey, is that a natural product?!

Aguniomycins – Synthesis and Biology

Posted by naturalproductman on January 7, 2010

Karl Gademann and co-workers at the Swiss Federal Institute have recently published in JACS on the synthesis of aguinomycins and its analogs in addition to the biological activity.  The natural product possessed strong CRM1-mediated nucleocytoplasmic transport inhibition at 10 nM while their analog with a shortened side chain caused accumulation of Rio2 protein in the nucleus at 25 nM.

aguinomycin

JACS paper

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