Naturalproductman’s Blog

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Synthesis of Mersicarpine

Posted by naturalproductman on January 7, 2010

Fukuyama and co-workers at the University of Tokyo have recently reported on a synthesis of mersicarpine.  A highlight of the synthesis includes a coupling between a haloaniline with an alkyne to form the indole moiety.  In addition, the Eschenmoser-Tanabe fragmentation to afford the alkyne fragment was pretty neat.

mersicarpine
JACS paper

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