Naturalproductman’s Blog

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Synthesis of Ent-Hyperforin

Posted by naturalproductman on January 11, 2010

Masakatsu Shibasaki and co-workers at the University of Tokyo have recently published in ACIEE on the total synthesis of ent-hyperforin, a polyprenylated acylphloroglucinol.  One of the key reactions was an asymmetric Diels-Alder cycloaddition that involved the use of a cationic iron complex using a chiral pybox ligand.

hyperforin

ACIEE paper

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