Naturalproductman’s Blog

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Tandem Oxidation-Wittig

Posted by naturalproductman on February 17, 2010

Richard Taylor and co-workers at the University of York have recently published in Synlett on a tandem approach to synthesize dibromo-beta-substituted enone from an alpha hydroxy ketone.   Hydrazine was condensed with the carbonyl and a Suzuki-Miyaura cross coupling followed to form a pyrazole ring.

tandem

Synlett paper

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