Naturalproductman’s Blog

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Diazonamide Synthesis

Posted by naturalproductman on February 28, 2010

Tarek Sammakia and co-workers at the University of Colorado at Boulder have recently published in ACIEE on a formal synthesis of diazonamide.  The key cyclization process involved an SnAr reaction, which displaces a bromide on the oxazole group.

snar

ACIEE paper

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