Synthesis of Echinopines A and B
Posted by naturalproductman on February 28, 2010
David Chen and co-workers at Institute of Chemical and Engineering Sciences in Singapore have recently published in JACS on the synthesis of echinopines where the key reactions involved the use of an alpha-diazo carbonyl intermediate to afford a cyclopropane ring and an SmI2-mediated intramolecular pinacol coupling between an aldehyde and ketone to form a seven membered ring.
This entry was posted on February 28, 2010 at 5:47 pm and is filed under Cascade Reactions, Methodology, Rhodium, Ring forming, Seven-Membered Rings, Transition Metal. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.