Naturalproductman’s Blog

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Taxol Studies

Posted by naturalproductman on March 16, 2010

Rudiger Kaspera, Rodney Croteau and co-workers at Washington State University have recently published in Tetrahedron Letters on an in vitro study of taxol’s oxetane ring formation by synthesizing radiolabeled potential taxol substrates.  However, none of the surrogate substrates synthesized underwent rearrangement to form the oxetane ring.


TL paper


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