Naturalproductman’s Blog

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Grecocycline B

Posted by naturalproductman on March 20, 2010

Thomas Paululat and co-workers at the University of Siegen in Germany have recently reported on the isolation of grecocycline B from Streptomyces sp. Acta 1362.  The new polycyclic compound had an IC50 of 0.52 micromolar against tyrosine phosphatase B1.  Interestingly, protein tyrosine phosphatase PTP1B is a target for the treatment of obesity, type 2 diabetes and cancer.
grecocycline B

European JOC paper

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