Naturalproductman’s Blog

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Linderol A Synthesis

Posted by naturalproductman on March 24, 2010

Hatice Berber and co-workers at CNRS have recently reported in JOC on the synthesis of linderol A.  They made the dihydrobenzofuran moiety via ring opening of an epoxide with a phenolic nucleophile.  This paper is the first one I’ve seen that showed the pictures of the TLC plates – they wanted to show that the rotamers can be separated by TLC at -20 degrees Celsius.


JOC paper

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