Naturalproductman’s Blog

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Making Enones

Posted by naturalproductman on April 12, 2010

The benzoin condensation takes advantage of umpolung chemistry where the aldehyde, which is normally an electrophile, is used as a nucleophile.  Frank Glorius and co-workers from Organisch-Chemisches Institut der Westfalischen Wilhelms-Universitat Munster have made use of this umpolung reactivity and used an alkyne as the reactant with the aldehyde.

aldehyde
JACS paper

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