Naturalproductman’s Blog

Hey, is that a natural product?!

Koshikamides

Posted by naturalproductman on April 20, 2010

Carole Bewley and co-workers at the NIH have isolated some peptides tested with the HIV-1 infectivity assay against a CCR5-using viral envelope in order to test their inhibition of HIV-1 entry.  Koshikamides F and H had inhibited HIV entry with IC50 values of 2.3 and 5.5 micromolar.

HIV inhibitor

JOC paper

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

 
%d bloggers like this: