Naturalproductman’s Blog

Hey, is that a natural product?!


Posted by naturalproductman on April 28, 2010

Yu-Dong Zhou and co-workers from the University of Mississippi have recently reported in the Journal of Natural Products on the isolation of some tetrahydrofuran containing compounds 10-hydroxyglaucanetin, annonacin, and annonacin A, which inhibited hypoxia-induced HIF-1 activation at IC50 values of 12 nM, 13 nM, and 31 nM.

paw paw crude extract

JNP paper


One Response to “Acetogenins”

  1. Interesting piece of news! Worth sharing among chemists…

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